1lof

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[[Image:1lof.jpg|left|200px]]
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{{Seed}}
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[[Image:1lof.png|left|200px]]
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{{STRUCTURE_1lof| PDB=1lof | SCENE= }}
{{STRUCTURE_1lof| PDB=1lof | SCENE= }}
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'''X-RAY STRUCTURE OF A BIANTENNARY OCTASACCHARIDE-LECTIN COMPLEX AT 2.3 ANGSTROMS RESOLUTION'''
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===X-RAY STRUCTURE OF A BIANTENNARY OCTASACCHARIDE-LECTIN COMPLEX AT 2.3 ANGSTROMS RESOLUTION===
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==Overview==
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The structure and flexibility of saccharides have a profound and specific influence in several biological processes such as protein protection and the maintenance of conformational integrity, and in recognition events involving viruses, enzymes, and lectins. To establish the structural bases of these phenomena, we describe herein the extensively refined 2.3-A resolution x-ray structure of a biantennary octasaccharide of the N-acetyllactosamine type, complexed to isolectin I from Lathyrus ochrus. The two octasaccharides are located in clefts at each end of the long axis of the lectin. The conformations of both the lectin and the saccharide are slightly modified upon binding. The complex is stabilized by numerous hydrogen bonds, many of them involving water molecules. It is also stabilized by van der Waals interactions, including some with aromatic residues. A more general model of a possible lectin-glycoprotein interaction is also proposed.
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The line below this paragraph, {{ABSTRACT_PUBMED_1730588}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1730588 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1730588}}
==About this Structure==
==About this Structure==
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[[Category: Cambillau, C.]]
[[Category: Cambillau, C.]]
[[Category: Lectin]]
[[Category: Lectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:07:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:35:29 2008''

Revision as of 18:35, 2 July 2008

Image:1lof.png

Template:STRUCTURE 1lof

X-RAY STRUCTURE OF A BIANTENNARY OCTASACCHARIDE-LECTIN COMPLEX AT 2.3 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 1730588

About this Structure

1LOF is a Protein complex structure of sequences from Lathyrus ochrus. Full crystallographic information is available from OCA.

Reference

X-ray structure of a biantennary octasaccharide-lectin complex refined at 2.3-A resolution., Bourne Y, Rouge P, Cambillau C, J Biol Chem. 1992 Jan 5;267(1):197-203. PMID:1730588

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