1lom

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[[Image:1lom.gif|left|200px]]
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{{STRUCTURE_1lom| PDB=1lom | SCENE= }}
{{STRUCTURE_1lom| PDB=1lom | SCENE= }}
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'''CYANOVIRIN-N DOUBLE MUTANT P51S S52P'''
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===CYANOVIRIN-N DOUBLE MUTANT P51S S52P===
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==Overview==
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Cyanovirin-N (CV-N) is a potent 11 kDa HIV-inactivating protein that binds with high affinity to the HIV surface envelope protein gp120. A double mutant P51S/S52P of CV-N was engineered by swapping two critical hinge-region residues Pro51 and Ser52. This mutant has biochemical and biophysical characteristics equivalent to the wild-type CV-N and its structure resembles that of wild-type CV-N. However, the mutant shows a different orientation in the hinge region that connects two domains of the protein. The observation that this double mutant crystallizes under a wide variety of conditions challenges some of the current hypotheses on domain swapping and on the role of hinge-region proline residues in domain orientation. The current structure contributes to the understanding of domain swapping in cyanovirins, permitting rational design of domain-swapped CV-N mutants.
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(as it appears on PubMed at http://www.pubmed.gov), where 12054761 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12054761}}
==About this Structure==
==About this Structure==
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[[Category: Gp120]]
[[Category: Gp120]]
[[Category: Hiv-inactivating]]
[[Category: Hiv-inactivating]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:07:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:36:23 2008''

Revision as of 18:36, 2 July 2008

Image:1lom.png

Template:STRUCTURE 1lom

CYANOVIRIN-N DOUBLE MUTANT P51S S52P

Template:ABSTRACT PUBMED 12054761

About this Structure

1LOM is a Single protein structure of sequence from Nostoc ellipsosporum. Full crystallographic information is available from OCA.

Reference

Domain-swapped structure of a mutant of cyanovirin-N., Botos I, Mori T, Cartner LK, Boyd MR, Wlodawer A, Biochem Biophys Res Commun. 2002 May 31;294(1):184-90. PMID:12054761

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