This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2rlq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2rlq.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2rlq.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2rlq| PDB=2rlq | SCENE= }}
{{STRUCTURE_2rlq| PDB=2rlq | SCENE= }}
-
'''NMR structure of CCP modules 2-3 of complement factor H'''
+
===NMR structure of CCP modules 2-3 of complement factor H===
-
==Overview==
+
<!--
-
Factor H is a regulatory glycoprotein of the complement system. We expressed the three N-terminal complement control protein modules of human factor H (FH[1-3]) and confirmed FH[1-3] to be the minimal unit with cofactor activity for C3b proteolysis by factor I. We reconstructed FH[1-3] from NMR-derived structures of FH[1-2] and FH[2-3] revealing an ~105-A long rod-like arrangement of the modules. In structural comparisons with other C3b-engaging proteins, factor H module 3 most closely resembles factor B module 3, consistent with factor H competing with factor B for binding C3b. Factor H modules 1, 2 and 3 each has a similar backbone structure to first, second and third modules, respectively, of functional sites in decay accelerating factor and complement receptor type 1; equivalent intermodular tilt and twist angles are also broadly similar. Resemblance between molecular surfaces is closest for first modules but absent in the case of second modules. Substitution of buried Val62 with Ile (a factor H single nucleotide polymorphism potentially protective for age-related macular degeneration and dense deposit disease) causes rearrangements within the module 1 core and increases thermal stability but does not disturb the interface with module 2. Replacement of partially exposed (in module 1) Arg53 by His (an atypical hemolytic uremic syndrome-linked mutation) did not impair structural integrity at 37 degrees C, but this FH[1-2] mutant was less stable at higher temperatures; furthermore, chemical shift differences indicated potential for small structural changes at the module 1-2 interface.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18252712}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18252712 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18252712}}
==About this Structure==
==About this Structure==
-
2RLQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLQ OCA].
+
2RLQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLQ OCA].
==Reference==
==Reference==
Line 43: Line 47:
[[Category: Secreted]]
[[Category: Secreted]]
[[Category: Sushi]]
[[Category: Sushi]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:08:41 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:41:32 2008''

Revision as of 18:41, 2 July 2008

Image:2rlq.png

Template:STRUCTURE 2rlq

NMR structure of CCP modules 2-3 of complement factor H

Template:ABSTRACT PUBMED 18252712

About this Structure

2RLQ is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations., Hocking HG, Herbert AP, Kavanagh D, Soares DC, Ferreira VP, Pangburn MK, Uhrin D, Barlow PN, J Biol Chem. 2008 Feb 5;. PMID:18252712

Page seeded by OCA on Wed Jul 2 21:41:32 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2rlq"
Personal tools