2vl8

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{{STRUCTURE_2vl8| PDB=2vl8 | SCENE= }}
{{STRUCTURE_2vl8| PDB=2vl8 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LETHAL TOXIN FROM CLOSTRIDIUM SORDELLII IN COMPLEX WITH UDP, CASTANOSPERMINE AND CALCIUM ION'''
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===CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LETHAL TOXIN FROM CLOSTRIDIUM SORDELLII IN COMPLEX WITH UDP, CASTANOSPERMINE AND CALCIUM ION===
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==Overview==
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Castanospermine was identified as an inhibitor of the Rho/Ras-glucosylating Clostridium sordellii lethal toxin and Clostridium difficile toxin B. Microinjection of castanospermine into embryonic bovine lung cells prevented the cytotoxic effects of toxins. The crystal structure of the glucosyltransferase domain of C. sordellii lethal toxin in complex with castanospermine, UDP and a calcium ion was solved at a resolution of 2.3A. The inhibitor binds in a conformation that brings its four hydroxyl groups and its N-atom almost exactly in the positions of the four hydroxyls and of the ring oxygen of the glucosyl moiety of UDP-glucose, respectively.
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(as it appears on PubMed at http://www.pubmed.gov), where 18505687 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18505687}}
==About this Structure==
==About this Structure==
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[[Category: Glycosyltransferase]]
[[Category: Glycosyltransferase]]
[[Category: Toxin]]
[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 18 12:04:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:44:47 2008''

Revision as of 18:44, 2 July 2008

Image:2vl8.png

Template:STRUCTURE 2vl8

CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LETHAL TOXIN FROM CLOSTRIDIUM SORDELLII IN COMPLEX WITH UDP, CASTANOSPERMINE AND CALCIUM ION

Template:ABSTRACT PUBMED 18505687

About this Structure

2VL8 is a Single protein structure of sequence from Clostridium sordellii. Full crystallographic information is available from OCA.

Reference

Inhibition of the glucosyltransferase activity of clostridial Rho/Ras-glucosylating toxins by castanospermine., Jank T, Ziegler MO, Schulz GE, Aktories K, FEBS Lett. 2008 Jun 25;582(15):2277-82. Epub 2008 May 27. PMID:18505687

Page seeded by OCA on Wed Jul 2 21:44:47 2008

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