1lpv

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[[Image:1lpv.jpg|left|200px]]
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[[Image:1lpv.png|left|200px]]
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{{STRUCTURE_1lpv| PDB=1lpv | SCENE= }}
{{STRUCTURE_1lpv| PDB=1lpv | SCENE= }}
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'''DROSOPHILA MELANOGASTER DOUBLESEX (DSX), NMR, 18 STRUCTURES'''
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===DROSOPHILA MELANOGASTER DOUBLESEX (DSX), NMR, 18 STRUCTURES===
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==Overview==
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Sex determination is regulated by diverse pathways. Although upstream signals vary, a cysteine-rich DNA-binding domain (the DM motif) is conserved within downstream transcription factors of Drosophila melanogaster (Doublesex) and Caenorhabditis elegans (MAB-3). Vertebrate DM genes have likewise been identified and, remarkably, are associated with human sex reversal (46, XY gonadal dysgenesis). Here we demonstrate that the structure of the Doublesex domain contains a novel zinc module and disordered tail. The module consists of intertwined CCHC and HCCC Zn(2+)-binding sites; the tail functions as a nascent recognition alpha-helix. Mutations in either Zn(2+)-binding site or tail can lead to an intersex phenotype. The motif binds in the DNA minor groove without sharp DNA bending. These molecular features, unusual among zinc fingers and zinc modules, underlie the organization of a Drosophila enhancer that integrates sex- and tissue-specific signals. The structure provides a foundation for analysis of DM mutations affecting sexual dimorphism and courtship behavior.
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(as it appears on PubMed at http://www.pubmed.gov), where 10898790 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10898790}}
==About this Structure==
==About this Structure==
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1LPV is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LPV OCA].
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1LPV is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LPV OCA].
==Reference==
==Reference==
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[[Category: Nmr]]
[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:09:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:45:40 2008''

Revision as of 18:45, 2 July 2008

Image:1lpv.png

Template:STRUCTURE 1lpv

DROSOPHILA MELANOGASTER DOUBLESEX (DSX), NMR, 18 STRUCTURES

Template:ABSTRACT PUBMED 10898790

About this Structure

1LPV is a Single protein structure. Full experimental information is available from OCA.

Reference

Sexual dimorphism in diverse metazoans is regulated by a novel class of intertwined zinc fingers., Zhu L, Wilken J, Phillips NB, Narendra U, Chan G, Stratton SM, Kent SB, Weiss MA, Genes Dev. 2000 Jul 15;14(14):1750-64. PMID:10898790

Page seeded by OCA on Wed Jul 2 21:45:40 2008

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