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1lpw

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[[Image:1lpw.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1lpw| PDB=1lpw | SCENE= }}
{{STRUCTURE_1lpw| PDB=1lpw | SCENE= }}
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'''Solution structure of the yeast spliceosomal U2 snRNA-intron branch site helix featuring a conserved pseudouridine'''
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===Solution structure of the yeast spliceosomal U2 snRNA-intron branch site helix featuring a conserved pseudouridine===
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==Overview==
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Pairing of a consensus sequence of the precursor (pre)-mRNA intron with a short region of the U2 small nuclear (sn)RNA during assembly of the eukaryotic spliceosome results in formation of a complementary helix of seven base pairs with a single unpaired adenosine residue. The 2' OH of this adenosine, called the branch site, brings about nucleophilic attack at the pre-mRNA 5' splice site in the first step of splicing. Another feature of this pairing is the phylogenetic conservation of a pseudouridine (psi) residue in U2 snRNA nearly opposite the branch site. We show that the presence of this psi in the pre-mRNA branch-site helix of Saccharomyces cerevisiae induces a dramatically altered architectural landscape compared with that of its unmodified counterpart. The psi-induced structure places the nucleophile in an accessible position for the first step of splicing.
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The line below this paragraph, {{ABSTRACT_PUBMED_12426583}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12426583 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12426583}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LPW OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LPW OCA].
==Reference==
==Reference==
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[[Category: Pseudouridine]]
[[Category: Pseudouridine]]
[[Category: U2 snrna]]
[[Category: U2 snrna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:09:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:45:59 2008''

Revision as of 18:46, 2 July 2008

Image:1lpw.png

Template:STRUCTURE 1lpw

Solution structure of the yeast spliceosomal U2 snRNA-intron branch site helix featuring a conserved pseudouridine

Template:ABSTRACT PUBMED 12426583

About this Structure

Full experimental information is available from OCA.

Reference

Sculpting of the spliceosomal branch site recognition motif by a conserved pseudouridine., Newby MI, Greenbaum NL, Nat Struct Biol. 2002 Dec;9(12):958-65. PMID:12426583

Page seeded by OCA on Wed Jul 2 21:45:59 2008

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