1lq7

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{{STRUCTURE_1lq7| PDB=1lq7 | SCENE= }}
{{STRUCTURE_1lq7| PDB=1lq7 | SCENE= }}
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'''De Novo Designed Protein Model of Radical Enzymes'''
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===De Novo Designed Protein Model of Radical Enzymes===
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==Overview==
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The use of side chains as catalytic cofactors for protein mediated redox chemistry raises significant mechanistic issues as to how these amino acids are activated toward radical chemistry in a controlled manner. De novo protein design has been used to examine the structural basis for the creation and maintenance of a tryptophanyl radical in a three-helix bundle protein maquette. Here we report the detailed structural analysis of the protein by multidimensional NMR methods. An interesting feature of the structure is an apparent pi-cation interaction involving the sole tryptophan and a lysine side chain. Hybrid density functional calculations support the notion that this interaction raises the reduction potential of the W degrees /WH redox pair and helps explain the redox characteristics of the protein. This model protein system therefore provides a powerful model for exploring the structural basis for controlled radical chemistry in protein.
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The line below this paragraph, {{ABSTRACT_PUBMED_12224922}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12224922 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12224922}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQ7 OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQ7 OCA].
==Reference==
==Reference==
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[[Category: Wand, A J.]]
[[Category: Wand, A J.]]
[[Category: Three helix bundle]]
[[Category: Three helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:10:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:46:28 2008''

Revision as of 18:46, 2 July 2008

Image:1lq7.png

Template:STRUCTURE 1lq7

De Novo Designed Protein Model of Radical Enzymes

Template:ABSTRACT PUBMED 12224922

About this Structure

Full experimental information is available from OCA.

Reference

Structure of a de novo designed protein model of radical enzymes., Dai QH, Tommos C, Fuentes EJ, Blomberg MR, Dutton PL, Wand AJ, J Am Chem Soc. 2002 Sep 18;124(37):10952-3. PMID:12224922

Page seeded by OCA on Wed Jul 2 21:46:28 2008

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