1lq8

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[[Image:1lq8.gif|left|200px]]
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{{STRUCTURE_1lq8| PDB=1lq8 | SCENE= }}
{{STRUCTURE_1lq8| PDB=1lq8 | SCENE= }}
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'''Crystal structure of cleaved protein C inhibitor'''
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===Crystal structure of cleaved protein C inhibitor===
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==Overview==
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Protein C inhibitor (PCI) is a member of the serpin family that has many biological functions. In blood it acts as a procoagulant, and, in the seminal vesicles, it is required for spermatogenesis. The activity of PCI is affected by heparin binding in a manner unique among the heparin binding serpins, and, in addition, PCI binds hydrophobic hormones with apparent specificity for retinoids. Here we present the 2.4 A crystallographic structure of reactive center loop (RCL) cleaved PCI. A striking feature of the structure is a two-turn N-terminal shortening of helix A, which creates a large hydrophobic pocket that docking studies indicate to be the retinoid binding site. On the basis of surface electrostatic properties, a novel mechanism for heparin activation is proposed.
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(as it appears on PubMed at http://www.pubmed.gov), where 12575940 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12575940}}
==About this Structure==
==About this Structure==
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[[Category: Retinoic acid]]
[[Category: Retinoic acid]]
[[Category: Serpin]]
[[Category: Serpin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:10:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:46:45 2008''

Revision as of 18:46, 2 July 2008

Image:1lq8.png

Template:STRUCTURE 1lq8

Crystal structure of cleaved protein C inhibitor

Template:ABSTRACT PUBMED 12575940

About this Structure

1LQ8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of protein C inhibitor provides insights into hormone binding and heparin activation., Huntington JA, Kjellberg M, Stenflo J, Structure. 2003 Feb;11(2):205-15. PMID:12575940

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