1lt7

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{{STRUCTURE_1lt7| PDB=1lt7 | SCENE= }}
{{STRUCTURE_1lt7| PDB=1lt7 | SCENE= }}
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'''Oxidized Homo sapiens betaine-homocysteine S-methyltransferase in complex with four Sm(III) ions'''
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===Oxidized Homo sapiens betaine-homocysteine S-methyltransferase in complex with four Sm(III) ions===
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==Overview==
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Betaine-homocysteine methyl transferase (BHMT) catalyzes the synthesis of methionine from betaine and homocysteine (Hcy), utilizing a zinc ion to activate Hcy. BHMT is a key liver enzyme that is important for homocysteine homeostasis. X-ray structures of human BHMT in its oxidized (Zn-free) and reduced (Zn-replete) forms, the latter in complex with the bisubstrate analog, S(delta-carboxybutyl)-L-homocysteine, were determined at resolutions of 2.15 A and 2.05 A. BHMT is a (beta/alpha)(8) barrel that is distorted to construct the substrate and metal binding sites. The zinc binding sequences G-V/L-N-C and G-G-C-C are at the C termini of strands beta6 and beta8. Oxidation to the Cys217-Cys299 disulfide and expulsion of Zn are accompanied by local rearrangements. The structures identify Hcy binding fingerprints and provide a prototype for the homocysteine S-methyltransferase family.
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(as it appears on PubMed at http://www.pubmed.gov), where 12220488 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12220488}}
==About this Structure==
==About this Structure==
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Zinc]]
[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:08:30 2008''

Revision as of 19:08, 2 July 2008

Image:1lt7.png

Template:STRUCTURE 1lt7

Oxidized Homo sapiens betaine-homocysteine S-methyltransferase in complex with four Sm(III) ions

Template:ABSTRACT PUBMED 12220488

About this Structure

1LT7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Betaine-homocysteine methyltransferase: zinc in a distorted barrel., Evans JC, Huddler DP, Jiracek J, Castro C, Millian NS, Garrow TA, Ludwig ML, Structure. 2002 Sep;10(9):1159-71. PMID:12220488

Page seeded by OCA on Wed Jul 2 22:08:30 2008

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