3ch6

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{{STRUCTURE_3ch6| PDB=3ch6 | SCENE= }}
{{STRUCTURE_3ch6| PDB=3ch6 | SCENE= }}
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'''Crystal Structure of 11beta-HSD1 Double Mutant (L262R, F278E) Complexed with (3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone'''
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===Crystal Structure of 11beta-HSD1 Double Mutant (L262R, F278E) Complexed with (3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone===
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==Overview==
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Several series of pyridine amides were identified as selective and potent 11beta-HSD1 inhibitors. The most potent inhibitors feature 2,6- or 3,5-disubstitution on the pyridine core. Various linkers (CH(2)SO(2), CH(2)S, CH(2)O, S, O, N, bond) between the distal aryl and central pyridyl groups are tolerated, and lipophilic amide groups are generally favored. On the distal aryl group, a number of substitutions are well tolerated. A crystal structure was obtained for a complex between 11beta-HSD1 and the most potent inhibitor in this series.
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The line below this paragraph, {{ABSTRACT_PUBMED_18485702}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18485702 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18485702}}
==About this Structure==
==About this Structure==
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[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Sdr]]
[[Category: Sdr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 10:49:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:08:44 2008''

Revision as of 19:08, 2 July 2008

Image:3ch6.png

Template:STRUCTURE 3ch6

Crystal Structure of 11beta-HSD1 Double Mutant (L262R, F278E) Complexed with (3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone

Template:ABSTRACT PUBMED 18485702

About this Structure

3CH6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1., Wang H, Ruan Z, Li JJ, Simpkins LM, Smirk RA, Wu SC, Hutchins RD, Nirschl DS, Van Kirk K, Cooper CB, Sutton JC, Ma Z, Golla R, Seethala R, Salyan ME, Nayeem A, Krystek SR Jr, Sheriff S, Camac DM, Morin PE, Carpenter B, Robl JA, Zahler R, Gordon DA, Hamann LG, Bioorg Med Chem Lett. 2008 Jun 1;18(11):3168-72. Epub 2008 May 1. PMID:18485702

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