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1lta

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{{STRUCTURE_1lta| PDB=1lta | SCENE= }}
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'''2.2 ANGSTROMS CRYSTAL STRUCTURE OF E. COLI HEAT-LABILE ENTEROTOXIN (LT) WITH BOUND GALACTOSE'''
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===2.2 ANGSTROMS CRYSTAL STRUCTURE OF E. COLI HEAT-LABILE ENTEROTOXIN (LT) WITH BOUND GALACTOSE===
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==Overview==
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The galactose-binding site in cholera toxin and the closely related heat-labile enterotoxin (LT) from Escherichia coli is an attractive target for the rational design of potential anti-cholera drugs. In this paper we analyse the molecular structure of this binding site as seen in several crystal structures, including that of an LT:galactose complex which we report here at 2.2 A resolution. The binding surface on the free toxin contains several tightly associated water molecules and a relatively flexible loop consisting of residues 51-60 of the B subunit. During receptor binding this loop becomes tightly ordered by forming hydrogen bonds jointly to the GM1 pentasaccharide and to a set of water molecules which stabilize the toxin:receptor complex.
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{{ABSTRACT_PUBMED_7997185}}
==About this Structure==
==About this Structure==
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[[Category: Zanten, B A.M Van.]]
[[Category: Zanten, B A.M Van.]]
[[Category: Enterotoxin]]
[[Category: Enterotoxin]]
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Revision as of 19:09, 2 July 2008

Image:1lta.png

Template:STRUCTURE 1lta

2.2 ANGSTROMS CRYSTAL STRUCTURE OF E. COLI HEAT-LABILE ENTEROTOXIN (LT) WITH BOUND GALACTOSE

Template:ABSTRACT PUBMED 7997185

About this Structure

1LTA is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Galactose-binding site in Escherichia coli heat-labile enterotoxin (LT) and cholera toxin (CT)., Merritt EA, Sixma TK, Kalk KH, van Zanten BA, Hol WG, Mol Microbiol. 1994 Aug;13(4):745-53. PMID:7997185

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