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1ltx

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{{STRUCTURE_1ltx| PDB=1ltx | SCENE= }}
{{STRUCTURE_1ltx| PDB=1ltx | SCENE= }}
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'''Structure of Rab Escort Protein-1 in complex with Rab geranylgeranyl transferase and isoprenoid'''
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===Structure of Rab Escort Protein-1 in complex with Rab geranylgeranyl transferase and isoprenoid===
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==Overview==
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Posttranslational geranylgeranylation of Rab GTPases is catalyzed by Rab geranylgeranyltransferase (RabGGTase), which consists of a catalytic alpha/beta heterodimer and an accessory Rab escort protein (REP). The crystal structure of isoprenoid-bound RabGGTase complexed to REP-1 has been solved to 2.7 A resolution. The complex interface buries a surprisingly small surface area of ca. 680 A and is unexpectedly formed by helices 8, 10, and 12 of the RabGGTase alpha subunit and helices D and E of REP-1. We demonstrate that the affinity of RabGGTase for REP-1 is allosterically regulated by phosphoisoprenoid via a long-range trans-domain signal transduction event. Comparing the structure of REP-1 with the closely related RabGDI, we conclude that the specificity of the REP:RabGGTase interaction is defined by differently positioned phenylalanine residues conserved in the REP and GDI subfamilies.
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The line below this paragraph, {{ABSTRACT_PUBMED_12620235}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12620235 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12620235}}
==About this Structure==
==About this Structure==
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[[Category: Prenyltransferase]]
[[Category: Prenyltransferase]]
[[Category: Rab prenylation]]
[[Category: Rab prenylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:17:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:13:19 2008''

Revision as of 19:13, 2 July 2008

Image:1ltx.png

Template:STRUCTURE 1ltx

Structure of Rab Escort Protein-1 in complex with Rab geranylgeranyl transferase and isoprenoid

Template:ABSTRACT PUBMED 12620235

About this Structure

1LTX is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase., Pylypenko O, Rak A, Reents R, Niculae A, Sidorovitch V, Cioaca MD, Bessolitsyna E, Thoma NH, Waldmann H, Schlichting I, Goody RS, Alexandrov K, Mol Cell. 2003 Feb;11(2):483-94. PMID:12620235

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