3cx5

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'''Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer.'''
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===Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer.===
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==Overview==
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In cellular respiration, cytochrome c transfers electrons from cytochrome bc1 complex (complex III) to cytochrome c oxidase by transiently binding to the membrane proteins. Here, we report the structure of isoform-1 cytochrome c bound to cytochrome bc1 complex at 1.9-A resolution in reduced state. The dimer structure is asymmetric. Monovalent cytochrome c binding is correlated with conformational changes of the Rieske head domain and subunit QCR6p and with a higher number of interfacial water molecules bound to cytochrome c1. Pronounced hydration and a 'mobility mismatch' at the interface with disordered charged residues on the cytochrome c side are favourable for transient binding. Within the hydrophobic interface, a minimal core was identified by comparison with the novel structure of the complex with bound isoform-2 cytochrome c. Four core interactions encircle the heme cofactors surrounded by variable interactions. The core interface may be a feature to gain specificity for formation of the reactive complex.
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==About this Structure==
==About this Structure==
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[[Category: Transit peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:23:37 2008''

Revision as of 19:23, 2 July 2008

Image:3cx5.png

Template:STRUCTURE 3cx5

Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer.

Template:ABSTRACT PUBMED 18390544

About this Structure

3CX5 is a Protein complex structure of sequences from Mus musculus and Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer., Solmaz S, Hunte C, J Biol Chem. 2008 Apr 4;. PMID:18390544

Page seeded by OCA on Wed Jul 2 22:23:37 2008

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