1lva

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{{STRUCTURE_1lva| PDB=1lva | SCENE= }}
{{STRUCTURE_1lva| PDB=1lva | SCENE= }}
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'''Crystal structure of a C-terminal fragment of Moorella thermoacetica elongation factor SelB'''
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===Crystal structure of a C-terminal fragment of Moorella thermoacetica elongation factor SelB===
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==Overview==
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SelB is an elongation factor needed for the co-translational incorporation of selenocysteine. Selenocysteine is coded by a UGA stop codon in combination with a specific downstream mRNA hairpin. In bacteria, the C-terminal part of SelB recognizes this hairpin, while the N-terminal part binds GTP and tRNA in analogy with elongation factor Tu (EF-Tu). We present the crystal structure of a C-terminal fragment of SelB (SelB-C) from Moorella thermoacetica at 2.12 A resolution, solved by a combination of selenium and yttrium multiwavelength anomalous dispersion. This 264 amino acid fragment contains the entire C-terminal extension beginning after the EF-Tu-homologous domains. SelB-C consists of four similar winged-helix domains arranged into the shape of an L. This is the first example of winged-helix domains involved in RNA binding. The location of conserved basic amino acids, together with data from the literature, define the position of the mRNA-binding site. Steric requirements indicate that a conformational change may occur upon ribosome interaction. Structural observations and data in the literature suggest that this change happens upon mRNA binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 12145214 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12145214}}
==About this Structure==
==About this Structure==
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[[Category: Su, X D.]]
[[Category: Su, X D.]]
[[Category: Winged-helix]]
[[Category: Winged-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:19:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:24:35 2008''

Revision as of 19:24, 2 July 2008

Image:1lva.png

Template:STRUCTURE 1lva

Crystal structure of a C-terminal fragment of Moorella thermoacetica elongation factor SelB

Template:ABSTRACT PUBMED 12145214

About this Structure

1LVA is a Single protein structure of sequence from Moorella thermoacetica. Full crystallographic information is available from OCA.

Reference

Crystal structure of an mRNA-binding fragment of Moorella thermoacetica elongation factor SelB., Selmer M, Su XD, EMBO J. 2002 Aug 1;21(15):4145-53. PMID:12145214

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