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1lvf

From Proteopedia

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[[Image:1lvf.gif|left|200px]]
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{{STRUCTURE_1lvf| PDB=1lvf | SCENE= }}
{{STRUCTURE_1lvf| PDB=1lvf | SCENE= }}
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'''syntaxin 6'''
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===syntaxin 6===
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==Overview==
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Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins are required for intracellular membrane fusion, and are differentially localized throughout the cell. SNAREs on vesicle and target membranes contain "SNARE motifs" which interact to form a four-helix bundle that contributes to the fusion of two membranes. SNARE motif sequences fall into four classes, homologous to the neuronal proteins syntaxin 1a, VAMP 2, and the N- and C-terminal SNARE motifs of SNAP-25 (S25N and S25C), and it is thought that one member from each class interacts to form a SNARE complex. Many SNAREs also feature N-terminal domains believed to function in regulating SNARE complex assembly or other aspects of vesicle transport. Syntaxin 6 is a SNARE found primarily in endosomal transport vesicles and whose SNARE motif shows significant homology to both syntaxin 1a and S25C. The crystal structure of the syntaxin 6 N-terminal domain reveals strong structural similarity with the N-terminal domains of syntaxin family members syntaxin 1a, Sso1p, and Vam3p, despite a very low level of sequence similarity. The syntaxin 6 SNARE motif can substitute for S25C in in vitro binding experiments, supporting the classification of syntaxin 6 as an S25C family member. Secondary structure prediction of SNARE proteins shows that the N-terminal domains of many syntaxin, S25N, and S25C family members are likely to be similar to one another, but are distinct from those of VAMP family members, indicating that syntaxin, S25N, and S25C SNAREs may have shared a common ancestor.
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(as it appears on PubMed at http://www.pubmed.gov), where 12082176 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12082176}}
==About this Structure==
==About this Structure==
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[[Category: Snare]]
[[Category: Snare]]
[[Category: Three-helix bundle]]
[[Category: Three-helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:19:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:25:30 2008''

Revision as of 19:25, 2 July 2008

Image:1lvf.png

Template:STRUCTURE 1lvf

syntaxin 6

Template:ABSTRACT PUBMED 12082176

About this Structure

1LVF is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the amino-terminal domain of syntaxin 6, a SNAP-25 C homolog., Misura KM, Bock JB, Gonzalez LC Jr, Scheller RH, Weis WI, Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9184-9. Epub 2002 Jun 24. PMID:12082176

Page seeded by OCA on Wed Jul 2 22:25:30 2008

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