1lvr

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[[Image:1lvr.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1lvr| PDB=1lvr | SCENE= }}
{{STRUCTURE_1lvr| PDB=1lvr | SCENE= }}
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'''IC3 of CB1 (L431A,A432L) Bound to G(alpha)i'''
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===IC3 of CB1 (L431A,A432L) Bound to G(alpha)i===
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==Overview==
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The structure of the C-terminal region of the third cytoplasmic loop (IC3) of the cannabinoid receptor one (CB1) bound to G(alphai1) has been determined using transferred nuclear Overhauser effects (NOEs). The wild-type IC3 sequence is helical when associated with G(alphai1). In contrast, a peptide containing the amino-acid inversion, Ala(341)-Leu(342) adopts a single turn. These findings correlate with the attenuated G(i) association of CB1 with the Ala(341)-Leu(342) mutation previously observed in vivo and the diminished stimulation of G(alphai1) GTPase activity by the corresponding peptide demonstrated in vitro here. These results, the first to report the structure of a GPCR domain while associated with G protein, imply the C-terminus of CB1 IC3, a region with high-sequence conservation among G-protein coupled receptors, must be helical for efficient coupling and activation of the G(i) protein.
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The line below this paragraph, {{ABSTRACT_PUBMED_12237474}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12237474 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12237474}}
==About this Structure==
==About this Structure==
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1LVR is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LVR OCA].
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1LVR is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LVR OCA].
==Reference==
==Reference==
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[[Category: Alpha domain of g protein i]]
[[Category: Alpha domain of g protein i]]
[[Category: Transferred no]]
[[Category: Transferred no]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:20:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:30:58 2008''

Revision as of 19:31, 2 July 2008

Image:1lvr.png

Template:STRUCTURE 1lvr

IC3 of CB1 (L431A,A432L) Bound to G(alpha)i

Template:ABSTRACT PUBMED 12237474

About this Structure

1LVR is a Single protein structure. Full experimental information is available from OCA.

Reference

Cannabinoid receptor-G protein interactions: G(alphai1)-bound structures of IC3 and a mutant with altered G protein specificity., Ulfers AL, McMurry JL, Miller A, Wang L, Kendall DA, Mierke DF, Protein Sci. 2002 Oct;11(10):2526-31. PMID:12237474

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