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1lwr

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[[Image:1lwr.gif|left|200px]]
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{{STRUCTURE_1lwr| PDB=1lwr | SCENE= }}
{{STRUCTURE_1lwr| PDB=1lwr | SCENE= }}
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'''Solution structure of the NCAM fibronectin type III module 2'''
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===Solution structure of the NCAM fibronectin type III module 2===
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==Overview==
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The neural cell adhesion molecule (NCAM) promotes axonal outgrowth, presumably through an interaction with the fibroblast growth factor receptor (FGFR). NCAM also has a little-understood ATPase activity. We here demonstrate for the first time a direct interaction between NCAM (fibronectin type III [F3] modules 1 and 2) and FGFR1 (Ig modules 2 and 3) by surface plasmon resonance (SPR) analysis. The structure of the NCAM F3 module 2 was determined by NMR and the module was shown by NMR to interact with the FGFR1 Ig module 3 and ATP. The NCAM sites binding to FGFR and ATP were found to overlap and ATP was shown by SPR to inhibit the NCAM-FGFR binding, indicating that ATP probably regulates the NCAM-FGFR interaction. Furthermore, we demonstrate that the NCAM module was able to induce activation (phosphorylation) of FGFR and to stimulate neurite outgrowth. In contrast, ATP inhibited neurite outgrowth induced by the module.
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The line below this paragraph, {{ABSTRACT_PUBMED_12791257}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12791257 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12791257}}
==About this Structure==
==About this Structure==
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1LWR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LWR OCA].
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1LWR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LWR OCA].
==Reference==
==Reference==
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[[Category: All beta]]
[[Category: All beta]]
[[Category: Fibronectin type iii module]]
[[Category: Fibronectin type iii module]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:22:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:43:15 2008''

Revision as of 19:43, 2 July 2008

Image:1lwr.png

Template:STRUCTURE 1lwr

Solution structure of the NCAM fibronectin type III module 2

Template:ABSTRACT PUBMED 12791257

About this Structure

1LWR is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP., Kiselyov VV, Skladchikova G, Hinsby AM, Jensen PH, Kulahin N, Soroka V, Pedersen N, Tsetlin V, Poulsen FM, Berezin V, Bock E, Structure. 2003 Jun;11(6):691-701. PMID:12791257

Page seeded by OCA on Wed Jul 2 22:43:15 2008

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