1lxe

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1lxe.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1lxe.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1lxe| PDB=1lxe | SCENE= }}
{{STRUCTURE_1lxe| PDB=1lxe | SCENE= }}
-
'''CRYSTAL STRUCTURE OF THE CATHELICIDIN MOTIF OF PROTEGRINS'''
+
===CRYSTAL STRUCTURE OF THE CATHELICIDIN MOTIF OF PROTEGRINS===
-
==Overview==
+
<!--
-
Cathelicidins are a family of antimicrobial proteins isolated from leucocytes and epithelia cells that contribute to the innate host defense mechanisms in mammalians. Located in the C-terminal part of the holoprotein, the cathelicidin-derived antimicrobial peptide is liberated by a specific protease cleavage. Here, we report the X-ray structure of the cathelicidin motif of protegrin-3 solved by MAD phasing using the selenocysteine-labeled protein. Its overall structure represents a fold homologous to the cystatin family and adopts two native states, a monomer, and a domain-swapped dimer. This crystal structure is the first example of a structural characterization of the highly conserved cathelicidin motif and thus provides insights into the possible mechanism of activation of the antimicrobial protegrin peptide.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12377122}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12377122 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12377122}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Domain swapping]]
[[Category: Domain swapping]]
[[Category: Protegrin]]
[[Category: Protegrin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:23:37 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:45:36 2008''

Revision as of 19:45, 2 July 2008

Image:1lxe.png

Template:STRUCTURE 1lxe

CRYSTAL STRUCTURE OF THE CATHELICIDIN MOTIF OF PROTEGRINS

Template:ABSTRACT PUBMED 12377122

About this Structure

1LXE is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Structure of the cathelicidin motif of protegrin-3 precursor: structural insights into the activation mechanism of an antimicrobial protein., Sanchez JF, Hoh F, Strub MP, Aumelas A, Dumas C, Structure. 2002 Oct;10(10):1363-70. PMID:12377122

Page seeded by OCA on Wed Jul 2 22:45:36 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1lxe"
Personal tools