1lyp

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{{STRUCTURE_1lyp| PDB=1lyp | SCENE= }}
{{STRUCTURE_1lyp| PDB=1lyp | SCENE= }}
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'''THE SOLUTION STRUCTURE OF THE ACTIVE DOMAIN OF CAP18: A LIPOPOLYSACCHARIDE BINDING PROTEIN FROM RABBIT LEUKOCYTES'''
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===THE SOLUTION STRUCTURE OF THE ACTIVE DOMAIN OF CAP18: A LIPOPOLYSACCHARIDE BINDING PROTEIN FROM RABBIT LEUKOCYTES===
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==Overview==
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We have employed the circular dichroism (CD) technique to characterize the solution structure of CAP18(106-137), a lipopolysaccharide (LPS) binding, antimicrobial protein, and its interaction with lipid A. Our results revealed that CAP18(106-137) may exist in at least three lipid A concentration-dependent, primarily helix conformations. The 'model' structure of CAP18(106-137) in 30% (v/v) TFE, determined by nuclear magnetic resonance (NMR) technique, was found to be a complete and very rigid helix. In this conformation, the cationic and hydrophobic groups of CAP18(106-137) are separated into patches and stripes in such a way that it can favorably interact with lipid A through either coulombic interaction with the diphosphoryl groups or hydrophobic interaction with the fatty acyl chains.
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{{ABSTRACT_PUBMED_7649303}}
==About this Structure==
==About this Structure==
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1LYP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LYP OCA].
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1LYP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LYP OCA].
==Reference==
==Reference==
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[[Category: Huang, T H.]]
[[Category: Huang, T H.]]
[[Category: Lipopolysaccharide-binding protein]]
[[Category: Lipopolysaccharide-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:50:07 2008''

Revision as of 19:50, 2 July 2008

Image:1lyp.png

Template:STRUCTURE 1lyp

THE SOLUTION STRUCTURE OF THE ACTIVE DOMAIN OF CAP18: A LIPOPOLYSACCHARIDE BINDING PROTEIN FROM RABBIT LEUKOCYTES

Template:ABSTRACT PUBMED 7649303

About this Structure

1LYP is a Single protein structure of sequence from Oryctolagus cuniculus. Full experimental information is available from OCA.

Reference

The solution structure of the active domain of CAP18--a lipopolysaccharide binding protein from rabbit leukocytes., Chen C, Brock R, Luh F, Chou PJ, Larrick JW, Huang RF, Huang TH, FEBS Lett. 1995 Aug 14;370(1-2):46-52. PMID:7649303

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