1lz0

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[[Image:1lz0.gif|left|200px]]
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{{Seed}}
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[[Image:1lz0.png|left|200px]]
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{{STRUCTURE_1lz0| PDB=1lz0 | SCENE= }}
{{STRUCTURE_1lz0| PDB=1lz0 | SCENE= }}
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'''Glycosyltransferase A'''
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===Glycosyltransferase A===
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==Overview==
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The human ABO(H) blood group antigens are produced by specific glycosyltransferase enzymes. An N-acetylgalactosaminyltransferase (GTA) uses a UDP-GalNAc donor to convert the H-antigen acceptor to the A antigen, whereas a galactosyltransferase (GTB) uses a UDP-galactose donor to convert the H-antigen acceptor to the B antigen. GTA and GTB differ only in the identity of four critical amino acid residues. Crystal structures at 1.8-1.32 A resolution of the GTA and GTB enzymes both free and in complex with disaccharide H-antigen acceptor and UDP reveal the basis for donor and acceptor specificity and show that only two of the critical amino acid residues are positioned to contact donor or acceptor substrates. Given the need for stringent stereo- and regioselectivity in this biosynthesis, these structures further demonstrate that the ability of the two enzymes to distinguish between the A and B donors is largely determined by a single amino acid residue.
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The line below this paragraph, {{ABSTRACT_PUBMED_12198488}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12198488 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12198488}}
==About this Structure==
==About this Structure==
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[[Category: Signal-anchor]]
[[Category: Signal-anchor]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:26:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:51:07 2008''

Revision as of 19:51, 2 July 2008

Image:1lz0.png

Template:STRUCTURE 1lz0

Glycosyltransferase A

Template:ABSTRACT PUBMED 12198488

About this Structure

1LZ0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structural basis for specificity in human ABO(H) blood group biosynthesis., Patenaude SI, Seto NO, Borisova SN, Szpacenko A, Marcus SL, Palcic MM, Evans SV, Nat Struct Biol. 2002 Sep;9(9):685-90. PMID:12198488

Page seeded by OCA on Wed Jul 2 22:51:07 2008

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