1m16

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[[Image:1m16.gif|left|200px]]
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{{Seed}}
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[[Image:1m16.png|left|200px]]
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{{STRUCTURE_1m16| PDB=1m16 | SCENE= }}
{{STRUCTURE_1m16| PDB=1m16 | SCENE= }}
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'''Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag and Leu 44 Replaced with Phe (L44F), Leu 73 Replaced with Val (L73V), Val 109 Replaced with Leu (V109L) and Cys 117 Replaced with Val (C117V).'''
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===Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag and Leu 44 Replaced with Phe (L44F), Leu 73 Replaced with Val (L73V), Val 109 Replaced with Leu (V109L) and Cys 117 Replaced with Val (C117V).===
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==Overview==
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An alternative core packing group, involving a set of five positions, has been introduced into human acidic FGF-1. This alternative group was designed so as to constrain the primary structure within the core region to the same threefold symmetry present in the tertiary structure of the protein fold (the beta-trefoil superfold). The alternative core is essentially indistinguishable from the WT core with regard to structure, stability, and folding kinetics. The results show that the beta-trefoil superfold is compatible with a threefold symmetric constraint on the core region, as might be the case if the superfold arose as a result of gene duplication/fusion events. Furthermore, this new core arrangement can form the basis of a structural "building block" that can greatly simplify the de novo design of beta-trefoil proteins by using symmetric structural complementarity. Remaining asymmetry within the core appears to be related to asymmetry in the tertiary structure associated with receptor and heparin binding functionality of the growth factor.
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The line below this paragraph, {{ABSTRACT_PUBMED_14627732}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14627732 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14627732}}
==About this Structure==
==About this Structure==
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[[Category: Spielmann, G L.]]
[[Category: Spielmann, G L.]]
[[Category: Beta-trefoil]]
[[Category: Beta-trefoil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:30:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:59:28 2008''

Revision as of 19:59, 2 July 2008

Image:1m16.png

Template:STRUCTURE 1m16

Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag and Leu 44 Replaced with Phe (L44F), Leu 73 Replaced with Val (L73V), Val 109 Replaced with Leu (V109L) and Cys 117 Replaced with Val (C117V).

Template:ABSTRACT PUBMED 14627732

About this Structure

1M16 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Accommodation of a highly symmetric core within a symmetric protein superfold., Brych SR, Kim J, Logan TM, Blaber M, Protein Sci. 2003 Dec;12(12):2704-18. PMID:14627732

Page seeded by OCA on Wed Jul 2 22:59:28 2008

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