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1m23

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[[Image:1m23.gif|left|200px]]
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{{STRUCTURE_1m23| PDB=1m23 | SCENE= }}
{{STRUCTURE_1m23| PDB=1m23 | SCENE= }}
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'''STRUCTURE OF THE DIMERIZED CYTOPLASMIC DOMAIN OF P23 IN SOLUTION'''
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===STRUCTURE OF THE DIMERIZED CYTOPLASMIC DOMAIN OF P23 IN SOLUTION===
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==Overview==
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Coatomer, the coat protein complex of COPI vesicles, is involved in the budding of these vesicles, but the underlying mechanism is unknown. Toward a better understanding of this process, the interaction between coatomer and the cytoplasmic domain of a major transmembrane protein of COPI vesicles, p23, was studied. Interaction of coatomer with this peptide domain results in a conformational change and polymerization of the complex in vitro. This changed conformation also is observed in vivo, i.e., on the surface of authentic, isolated COPI vesicles. An average of four peptides was found associated with one coatomer complex after polymerization. Based on these results, we propose a mechanism by which the induced conformational change of coatomer results in its polymerization, and thus drives formation of the bud on the Golgi membrane during biogenesis of a COPI vesicle.
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The line below this paragraph, {{ABSTRACT_PUBMED_9990005}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9990005 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9990005}}
==About this Structure==
==About this Structure==
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1M23 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M23 OCA].
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1M23 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M23 OCA].
==Reference==
==Reference==
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[[Category: Transport]]
[[Category: Transport]]
[[Category: Vesicular transport]]
[[Category: Vesicular transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:32:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:03:15 2008''

Revision as of 20:03, 2 July 2008

Image:1m23.png

Template:STRUCTURE 1m23

STRUCTURE OF THE DIMERIZED CYTOPLASMIC DOMAIN OF P23 IN SOLUTION

Template:ABSTRACT PUBMED 9990005

About this Structure

1M23 is a Single protein structure. Full experimental information is available from OCA.

Reference

Receptor-induced polymerization of coatomer., Reinhard C, Harter C, Bremser M, Brugger B, Sohn K, Helms JB, Wieland F, Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1224-8. PMID:9990005

Page seeded by OCA on Wed Jul 2 23:03:15 2008

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