1m24

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{{STRUCTURE_1m24| PDB=1m24 | SCENE= }}
{{STRUCTURE_1m24| PDB=1m24 | SCENE= }}
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'''Trichotoxin_A50E, An Ion Channel-Forming Polypeptide'''
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===Trichotoxin_A50E, An Ion Channel-Forming Polypeptide===
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==Overview==
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Trichotoxin_A50E is an 18-residue peptaibol antibiotic which forms multimeric transmembrane channels through self-association. The crystal structure of trichotoxin has been determined at a resolution of 0.9 A. The trichotoxin sequence contains nine helix-promoting Aib residues, which contribute to the formation of an entirely helical structure that has a central bend of 8-10 degrees located between residues 10-13. Trichotoxin is the first solved structure of the peptaibol family that is all alpha-helix as opposed to containing part or all 3(10)-helix. Gln residues in positions 6 and 17 produce a polar face, and are proposed to form the channel lumen. An octameric model channel has been constructed from the crystal structure. It has a central pore of approximately 4-5 A radius, a size sufficient to enable transport of ions, with a constricted region at one end, formed by a ring of Gln6 residues. Electrostatic calculations are consistent with it being a cationic channel.
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{{ABSTRACT_PUBMED_12390019}}
==About this Structure==
==About this Structure==
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[[Category: Ion channel]]
[[Category: Ion channel]]
[[Category: Peptaibol]]
[[Category: Peptaibol]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:32:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:03:37 2008''

Revision as of 20:03, 2 July 2008

Image:1m24.png

Template:STRUCTURE 1m24

Trichotoxin_A50E, An Ion Channel-Forming Polypeptide

Template:ABSTRACT PUBMED 12390019

About this Structure

Full crystallographic information is available from OCA.

Reference

Model for a helical bundle channel based on the high-resolution crystal structure of trichotoxin_A50E., Chugh JK, Bruckner H, Wallace BA, Biochemistry. 2002 Oct 29;41(43):12934-41. PMID:12390019

Page seeded by OCA on Wed Jul 2 23:03:37 2008

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