1m3v

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[[Image:1m3v.jpg|left|200px]]
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{{STRUCTURE_1m3v| PDB=1m3v | SCENE= }}
{{STRUCTURE_1m3v| PDB=1m3v | SCENE= }}
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'''FLIN4: Fusion of the LIM binding domain of Ldb1 and the N-terminal LIM domain of LMO4'''
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===FLIN4: Fusion of the LIM binding domain of Ldb1 and the N-terminal LIM domain of LMO4===
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==Overview==
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LMO2 and LMO4 are members of a small family of nuclear transcriptional regulators that are important for both normal development and disease processes. LMO2 is essential for hemopoiesis and angiogenesis, and inappropriate overexpression of this protein leads to T-cell leukemias. LMO4 is developmentally regulated in the mammary gland and has been implicated in breast oncogenesis. Both proteins comprise two tandemly repeated LIM domains. LMO2 and LMO4 interact with the ubiquitous nuclear adaptor protein ldb1/NLI/CLIM2, which associates with the LIM domains of LMO and LIM homeodomain proteins via its LIM interaction domain (ldb1-LID). We report the solution structures of two LMO:ldb1 complexes (PDB: 1M3V and 1J2O) and show that ldb1-LID binds to the N-terminal LIM domain (LIM1) of LMO2 and LMO4 in an extended conformation, contributing a third strand to a beta-hairpin in LIM1 domains. These findings constitute the first molecular definition of LIM-mediated protein-protein interactions and suggest a mechanism by which ldb1 can bind a variety of LIM domains that share low sequence homology.
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(as it appears on PubMed at http://www.pubmed.gov), where 12727888 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12727888}}
==About this Structure==
==About this Structure==
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1M3V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M3V OCA].
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1M3V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M3V OCA].
==Reference==
==Reference==
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[[Category: Lim domain]]
[[Category: Lim domain]]
[[Category: Lmo protein]]
[[Category: Lmo protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:35:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:08:44 2008''

Revision as of 20:08, 2 July 2008

Image:1m3v.png

Template:STRUCTURE 1m3v

FLIN4: Fusion of the LIM binding domain of Ldb1 and the N-terminal LIM domain of LMO4

Template:ABSTRACT PUBMED 12727888

About this Structure

1M3V is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4., Deane JE, Mackay JP, Kwan AH, Sum EY, Visvader JE, Matthews JM, EMBO J. 2003 May 1;22(9):2224-33. PMID:12727888

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