1m4e

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[[Image:1m4e.gif|left|200px]]
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{{STRUCTURE_1m4e| PDB=1m4e | SCENE= }}
{{STRUCTURE_1m4e| PDB=1m4e | SCENE= }}
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'''Solution Structure of Hepcidin-20'''
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===Solution Structure of Hepcidin-20===
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==Overview==
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The antibacterial and antifungal peptide hepcidin (LEAP-1) is expressed in the liver. This circulating peptide has recently been found to also act as a signaling molecule in iron metabolism. As such, it plays an important role in hereditary hemochromatosis, a serious iron overload disease. In this study, we report the solution structures of the hepcidin-20 and -25 amino acid peptides determined by standard two-dimensional (1)H NMR spectroscopy. These small cysteine-rich peptides form a distorted beta-sheet with an unusual vicinal disulfide bridge found at the turn of the hairpin, which is probably of functional significance. Both peptides exhibit an overall amphipathic structure with six of the eight Cys involved in maintaining interstrand connectivity. Hepcidin-25 assumes major and minor conformations centered about the Pro residue near the N-terminal end. Further NMR diffusion studies indicate that hepcidin-20 exists as a monomer in solution, whereas hepcidin-25 readily aggregates, a property that may contribute to the different activities of the two peptides. The nuclear Overhauser enhancement spectroscopy spectra of the hepcidin-25 aggregates indicate an interface for peptide interactions that again involves the first five residues from the N-terminal end.
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The line below this paragraph, {{ABSTRACT_PUBMED_12138110}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12138110 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12138110}}
==About this Structure==
==About this Structure==
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1M4E is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4E OCA].
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1M4E is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4E OCA].
==Reference==
==Reference==
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[[Category: Hairpin loop]]
[[Category: Hairpin loop]]
[[Category: Strand-loop-strand]]
[[Category: Strand-loop-strand]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:37:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:11:08 2008''

Revision as of 20:11, 2 July 2008

Image:1m4e.png

Template:STRUCTURE 1m4e

Solution Structure of Hepcidin-20

Template:ABSTRACT PUBMED 12138110

About this Structure

1M4E is a Single protein structure. Full experimental information is available from OCA.

Reference

The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis., Hunter HN, Fulton DB, Ganz T, Vogel HJ, J Biol Chem. 2002 Oct 4;277(40):37597-603. Epub 2002 Jul 22. PMID:12138110

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