1m4p

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{{STRUCTURE_1m4p| PDB=1m4p | SCENE= }}
{{STRUCTURE_1m4p| PDB=1m4p | SCENE= }}
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'''Structure of the Tsg101 UEV domain in complex with a HIV-1 PTAP "late domain" peptide, DYANA Ensemble'''
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===Structure of the Tsg101 UEV domain in complex with a HIV-1 PTAP "late domain" peptide, DYANA Ensemble===
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==Overview==
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The structural proteins of HIV and Ebola display PTAP peptide motifs (termed 'late domains') that recruit the human protein Tsg101 to facilitate virus budding. Here we present the solution structure of the UEV (ubiquitin E2 variant) binding domain of Tsg101 in complex with a PTAP peptide that spans the late domain of HIV-1 p6(Gag). The UEV domain of Tsg101 resembles E2 ubiquitin-conjugating enzymes, and the PTAP peptide binds in a bifurcated groove above the vestigial enzyme active site. Each PTAP residue makes important contacts, and the Ala 9-Pro 10 dipeptide binds in a deep pocket of the UEV domain that resembles the X-Pro binding pockets of SH3 and WW domains. The structure reveals the molecular basis of HIV PTAP late domain function and represents an attractive starting point for the design of novel inhibitors of virus budding.
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(as it appears on PubMed at http://www.pubmed.gov), where 12379843 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12379843}}
==About this Structure==
==About this Structure==
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1M4P is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4P OCA].
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1M4P is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4P OCA].
==Reference==
==Reference==
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[[Category: Vacuolar protein sorting]]
[[Category: Vacuolar protein sorting]]
[[Category: Virus budding]]
[[Category: Virus budding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:37:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:12:08 2008''

Revision as of 20:12, 2 July 2008

Image:1m4p.png


PDB ID 1m4p

Drag the structure with the mouse to rotate
1m4p, 20 NMR models ()
Gene: tumor susceptibility gene 101 (Homo sapiens), Gag (Human immunodeficiency virus 1)
Related: 1kpp, 1kpq, 1m4q
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Structure of the Tsg101 UEV domain in complex with a HIV-1 PTAP "late domain" peptide, DYANA Ensemble

Template:ABSTRACT PUBMED 12379843

About this Structure

1M4P is a Protein complex structure of sequences from Homo sapiens and Human immunodeficiency virus 1. Full experimental information is available from OCA.

Reference

Structure of the Tsg101 UEV domain in complex with the PTAP motif of the HIV-1 p6 protein., Pornillos O, Alam SL, Davis DR, Sundquist WI, Nat Struct Biol. 2002 Nov;9(11):812-7. PMID:12379843

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