1m4r

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{{Seed}}
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{{STRUCTURE_1m4r| PDB=1m4r | SCENE= }}
{{STRUCTURE_1m4r| PDB=1m4r | SCENE= }}
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'''CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-22'''
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===CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-22===
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==Overview==
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Interleukin-22 (IL-10-related T cell-derived inducible factor/IL-TIF/IL-22) is a novel cytokine belonging to the IL-10 family. Recombinant human IL-22 (hIL-22) was found to activate the signal transducers and activators of transcription factors 1 and 3 as well as acute phase reactants in several hepatoma cell lines, suggesting its involvement in the inflammatory response. The crystallographic structure of recombinant hIL-22 has been solved at 2.0 A resolution using the SIRAS method. Contrary to IL-10, the hIL-22 dimer does not present an interpenetration of the secondary-structure elements belonging to the two distinct polypeptide chains but results from interface interactions between monomers. Structural differences between these two cytokines, revealed by the crystallographic studies, clearly indicate that, while a homodimer of IL-10 is required for signaling, hIL-22 most probably interacts with its receptor as a monomer.
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The line below this paragraph, {{ABSTRACT_PUBMED_12176383}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12176383 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12176383}}
==About this Structure==
==About this Structure==
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[[Category: Cytokine]]
[[Category: Cytokine]]
[[Category: Interferon-gamma]]
[[Category: Interferon-gamma]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:37:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:12:21 2008''

Revision as of 20:12, 2 July 2008

Image:1m4r.png

Template:STRUCTURE 1m4r

CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-22

Template:ABSTRACT PUBMED 12176383

About this Structure

1M4R is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of recombinant human interleukin-22., Nagem RA, Colau D, Dumoutier L, Renauld JC, Ogata C, Polikarpov I, Structure. 2002 Aug;10(8):1051-62. PMID:12176383

Page seeded by OCA on Wed Jul 2 23:12:21 2008

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