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1m55

From Proteopedia

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[[Image:1m55.gif|left|200px]]
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{{STRUCTURE_1m55| PDB=1m55 | SCENE= }}
{{STRUCTURE_1m55| PDB=1m55 | SCENE= }}
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'''Catalytic domain of the Adeno Associated Virus type 5 Rep protein'''
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===Catalytic domain of the Adeno Associated Virus type 5 Rep protein===
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==Overview==
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Adeno-associated virus (AAV), unique among animal viruses in its ability to integrate into a specific chromosomal location, is a promising vector for human gene therapy. AAV Replication (Rep) protein is essential for viral replication and integration, and its amino terminal domain possesses site-specific DNA binding and endonuclease activities required for replication initiation and integration. This domain displays a novel endonuclease fold and demonstrates an unexpected structural relationship to other viral origin binding proteins such as the papillomavirus E1 protein and the SV40 T antigen. The active site, located at the bottom of a positively charged cleft, is formed by the spatial convergence of a divalent metal ion and two conserved sequence motifs that define the rolling circle replication superfamily.
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(as it appears on PubMed at http://www.pubmed.gov), where 12191478 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12191478}}
==About this Structure==
==About this Structure==
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[[Category: Rep]]
[[Category: Rep]]
[[Category: Rolling circle replication]]
[[Category: Rolling circle replication]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:38:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:13:57 2008''

Revision as of 20:13, 2 July 2008

Image:1m55.png

Template:STRUCTURE 1m55

Catalytic domain of the Adeno Associated Virus type 5 Rep protein

Template:ABSTRACT PUBMED 12191478

About this Structure

1M55 is a Single protein structure of sequence from Adeno-associated virus - 5. Full crystallographic information is available from OCA.

Reference

Structural unity among viral origin binding proteins: crystal structure of the nuclease domain of adeno-associated virus Rep., Hickman AB, Ronning DR, Kotin RM, Dyda F, Mol Cell. 2002 Aug;10(2):327-37. PMID:12191478

Page seeded by OCA on Wed Jul 2 23:13:57 2008

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