1m57

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[[Image:1m57.gif|left|200px]]
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{{STRUCTURE_1m57| PDB=1m57 | SCENE= }}
{{STRUCTURE_1m57| PDB=1m57 | SCENE= }}
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'''Structure of cytochrome c oxidase from Rhodobacter sphaeroides (EQ(I-286) mutant))'''
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===Structure of cytochrome c oxidase from Rhodobacter sphaeroides (EQ(I-286) mutant))===
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==Overview==
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The structure of cytochrome c oxidase from Rhodobacter sphaeroides has been solved at 2.3/2.8A (anisotropic resolution). This high-resolution structure revealed atomic details of a bacterial terminal oxidase including water molecule positions and a potential oxygen pathway, which has not been reported in other oxidase structures. A comparative study of the wild-type and the EQ(I-286) mutant enzyme revealed structural rearrangements around E(I-286) that could be crucial for proton transfer in this enzyme. In the structure of the mutant enzyme, EQ(I-286), which cannot transfer protons during oxygen reduction, the side-chain of Q(I-286) does not have the hydrogen bond to the carbonyl oxygen of M(I-107) that is seen in the wild-type structure. Furthermore, the Q(I-286) mutant has a different arrangement of water molecules and residues in the vicinity of the Q side-chain. These differences between the structures could reflect conformational changes that take place upon deprotonation of E(I-286) during turnover of the wild-type enzyme, which could be part of the proton-pumping machinery of the enzyme.
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(as it appears on PubMed at http://www.pubmed.gov), where 12144789 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12144789}}
==About this Structure==
==About this Structure==
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[[Category: Tornroth, S.]]
[[Category: Tornroth, S.]]
[[Category: Membrane protein]]
[[Category: Membrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:38:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:14:15 2008''

Revision as of 20:14, 2 July 2008

Image:1m57.png

Template:STRUCTURE 1m57

Structure of cytochrome c oxidase from Rhodobacter sphaeroides (EQ(I-286) mutant))

Template:ABSTRACT PUBMED 12144789

About this Structure

1M57 is a Protein complex structure of sequences from Rhodobacter sphaeroides. Full crystallographic information is available from OCA.

Reference

The X-ray crystal structures of wild-type and EQ(I-286) mutant cytochrome c oxidases from Rhodobacter sphaeroides., Svensson-Ek M, Abramson J, Larsson G, Tornroth S, Brzezinski P, Iwata S, J Mol Biol. 2002 Aug 9;321(2):329-39. PMID:12144789

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