1m5o

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[[Image:1m5o.gif|left|200px]]
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{{Seed}}
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[[Image:1m5o.png|left|200px]]
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{{STRUCTURE_1m5o| PDB=1m5o | SCENE= }}
{{STRUCTURE_1m5o| PDB=1m5o | SCENE= }}
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'''Transition State Stabilization by a Catalytic RNA'''
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===Transition State Stabilization by a Catalytic RNA===
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==Overview==
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The hairpin ribozyme catalyzes sequence-specific cleavage of RNA through transesterification of the scissile phosphate. Vanadate has previously been used as a transition state mimic of protein enzymes that catalyze the same reaction. Comparison of the 2.2 angstrom resolution structure of a vanadate-hairpin ribozyme complex with structures of precursor and product complexes reveals a rigid active site that makes more hydrogen bonds to the transition state than to the precursor or product. Because of the paucity of RNA functional groups capable of general acid-base or electrostatic catalysis, transition state stabilization is likely to be an important catalytic strategy for ribozymes.
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The line below this paragraph, {{ABSTRACT_PUBMED_12376595}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12376595 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12376595}}
==About this Structure==
==About this Structure==
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[[Category: U1a rna binding protein]]
[[Category: U1a rna binding protein]]
[[Category: Vandate]]
[[Category: Vandate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:39:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:16:04 2008''

Revision as of 20:16, 2 July 2008

Image:1m5o.png

Template:STRUCTURE 1m5o

Transition State Stabilization by a Catalytic RNA

Template:ABSTRACT PUBMED 12376595

About this Structure

1M5O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Transition state stabilization by a catalytic RNA., Rupert PB, Massey AP, Sigurdsson ST, Ferre-D'Amare AR, Science. 2002 Nov 15;298(5597):1421-4. Epub 2002 Oct 10. PMID:12376595

Page seeded by OCA on Wed Jul 2 23:16:04 2008

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