1m5z

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[[Image:1m5z.jpg|left|200px]]
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{{Seed}}
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[[Image:1m5z.png|left|200px]]
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{{STRUCTURE_1m5z| PDB=1m5z | SCENE= }}
{{STRUCTURE_1m5z| PDB=1m5z | SCENE= }}
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'''The PDZ7 of Glutamate Receptor Interacting Protein Binds to its Target via a Novel Hydrophobic Surface Area'''
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===The PDZ7 of Glutamate Receptor Interacting Protein Binds to its Target via a Novel Hydrophobic Surface Area===
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==Overview==
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Glutamate receptor interacting protein 1 (GRIP1) is a scaffold protein composed of seven PDZ (Postsynaptic synaptic density-95/Discs large/Zona occludens-1) domains. The protein plays important roles in the synaptic targeting of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. The interaction between GRIP1 PDZ7 and a Ras guanine nucleotide exchange factor, GRASP-1, regulates synaptic distribution of AMPA receptors. Here, we describe the three-dimensional structure of GRIP1 PDZ7 determined by NMR spectroscopy. GRIP1 PDZ7 contains a closed carboxyl group-binding pocket and a narrow alphaB/betaB-groove that is not likely to bind to classical PDZ ligands. Unexpectedly, GRIP1 PDZ7 contains a large solvent-exposed hydrophobic surface at a site distinct from the conventional ligand-binding alphaB/betaB-groove. NMR titration experiments show that GRIP1 PDZ7 binds to GRASP-1 via this hydrophobic surface. Our data uncover a novel PDZ domain-mediated protein interaction mode that may be responsible for multimerization of other PDZ domain-containing scaffold proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 12196542 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12196542}}
==About this Structure==
==About this Structure==
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1M5Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M5Z OCA].
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1M5Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M5Z OCA].
==Reference==
==Reference==
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[[Category: Zhang, M.]]
[[Category: Zhang, M.]]
[[Category: Six beta-strands and two alpha-helice]]
[[Category: Six beta-strands and two alpha-helice]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:40:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:17:14 2008''

Revision as of 20:17, 2 July 2008

Image:1m5z.png

Template:STRUCTURE 1m5z

The PDZ7 of Glutamate Receptor Interacting Protein Binds to its Target via a Novel Hydrophobic Surface Area

Template:ABSTRACT PUBMED 12196542

About this Structure

1M5Z is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

PDZ7 of glutamate receptor interacting protein binds to its target via a novel hydrophobic surface area., Feng W, Fan JS, Jiang M, Shi YW, Zhang M, J Biol Chem. 2002 Oct 25;277(43):41140-6. Epub 2002 Aug 23. PMID:12196542

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