1m6d

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{{STRUCTURE_1m6d| PDB=1m6d | SCENE= }}
{{STRUCTURE_1m6d| PDB=1m6d | SCENE= }}
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'''Crystal structure of human cathepsin F'''
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===Crystal structure of human cathepsin F===
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==Overview==
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Cathepsin F is a lysosomal cysteine protease of the papain family, and likely plays a regulatory role in processing the invariant chain that is associated with the major histocompatibility complex (MHC) class II. Evidence suggests that inhibiting cathepsin F activity will block MHC class II processing in macrophages. Consequently, inhibitors of this enzyme may be useful in treating certain diseases that involve an inappropriate or excessive immune response. We have determined the 1.7A structure of the mature domain of human cathepsin F associated with an irreversible vinyl sulfone inhibitor. This structure provides a basis for understanding cathepsin F's substrate specificity, and suggests ways of identifying potent and selective inhibitors of this enzyme.
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(as it appears on PubMed at http://www.pubmed.gov), where 12225749 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12225749}}
==About this Structure==
==About this Structure==
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[[Category: Somoza, J R.]]
[[Category: Somoza, J R.]]
[[Category: Papain family cysteine protease]]
[[Category: Papain family cysteine protease]]
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Revision as of 20:18, 2 July 2008

Image:1m6d.png

Template:STRUCTURE 1m6d

Crystal structure of human cathepsin F

Template:ABSTRACT PUBMED 12225749

About this Structure

1M6D is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators., Somoza JR, Palmer JT, Ho JD, J Mol Biol. 2002 Sep 20;322(3):559-68. PMID:12225749

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