1m6r

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{{STRUCTURE_1m6r| PDB=1m6r | SCENE= }}
{{STRUCTURE_1m6r| PDB=1m6r | SCENE= }}
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'''Crystal structure of rGd(CGCGCG) forming hexamer Z-DNA duplex with 5'-(rG) overhang'''
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===Crystal structure of rGd(CGCGCG) forming hexamer Z-DNA duplex with 5'-(rG) overhang===
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==Overview==
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The crystal structure of the heptamer rGd(CGCGCG) has been determined at 1.54 A resolution with R(work) and R(free) of 0.191 and 0.235, respectively. The crystal belongs to space group P2(1)2(1)2(1), with unit-cell parameters a = 17.96, b = 31.47, c = 44.73 A and two independent strands in the asymmetric unit. The chimera forms a Z-DNA hexamer duplex d(CGCGCG)(2), with the 5'-overhang rG invisible in the density. The replacement of rG in the 5' terminus of d(GCGCGCG) changes the reverse Hoogsteen G.G base pairing of the 5'-overhang dG (Pan et al., 1997). However, the replacement does not change the helix from Z-form to A-form or the water-structure motifs in the Z-DNA double-helical structure.
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(as it appears on PubMed at http://www.pubmed.gov), where 12595699 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12595699}}
==About this Structure==
==About this Structure==
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[[Category: Overhang]]
[[Category: Overhang]]
[[Category: Z-dna]]
[[Category: Z-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:42:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:20:03 2008''

Revision as of 20:20, 2 July 2008

Image:1m6r.png

Template:STRUCTURE 1m6r

Crystal structure of rGd(CGCGCG) forming hexamer Z-DNA duplex with 5'-(rG) overhang

Template:ABSTRACT PUBMED 12595699

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of rGd(CGCGCG): a Z-DNA hexamer duplex with a 5'-(rG) overhang., Pan B, Sundaralingam M, Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):433-7. Epub 2003, Feb 21. PMID:12595699

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