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1m77

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{{STRUCTURE_1m77| PDB=1m77 | SCENE= }}
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'''Near Atomic Resolution Crystal Structure of an A-DNA Decamer d(CCCGATCGGG): Cobalt Hexammine Interactions with A-DNA'''
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===Near Atomic Resolution Crystal Structure of an A-DNA Decamer d(CCCGATCGGG): Cobalt Hexammine Interactions with A-DNA===
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==Overview==
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The structure of the DNA decamer d(CCCGATCGGG) has been determined at 1.25 A resolution. The decamer crystallized in the tetragonal space group P4(3)2(1)2, with unit-cell parameters a = b = 44.3, c = 24.8 A and one strand in the asymmetric unit. The structure was solved by the molecular-replacement method and refined to R(work) and R(free) values of 16.3 and 18.5%, respectively, for 5969 reflections. The decamer forms the A-form DNA duplex, with the abutting crystal packing typical of A-DNA. The crystal packing interactions seem to distort the local conformation: A5 adopts the trans/trans conformation for the torsion angles alpha and gamma instead of the usual gauche(-)/gauche(+) conformations, yielding G*(G.C) base triplets. The highly hydrated [Co(NH(3))(6)](3+) ion adopts a novel binding mode to the DNA duplex, binding directly to phosphate groups and connecting to N7 and O6 atoms of guanines by water bridges. Analysis of thermal parameters (B factors) shows that the nucleotides involved in abutting crystal packing are thermally more stable than other nucleotides in the duplex.
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{{ABSTRACT_PUBMED_12499541}}
==About this Structure==
==About this Structure==
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[[Category: A-dna]]
[[Category: A-dna]]
[[Category: Cobalt hexammine]]
[[Category: Cobalt hexammine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:43:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:22:00 2008''

Revision as of 20:22, 2 July 2008

Image:1m77.png

Template:STRUCTURE 1m77

Near Atomic Resolution Crystal Structure of an A-DNA Decamer d(CCCGATCGGG): Cobalt Hexammine Interactions with A-DNA

Template:ABSTRACT PUBMED 12499541

About this Structure

Full crystallographic information is available from OCA.

Reference

Near-atomic resolution crystal structure of an A-DNA decamer d(CCCGATCGGG): cobalt hexammine interaction with A-DNA., Ramakrishnan B, Sekharudu C, Pan B, Sundaralingam M, Acta Crystallogr D Biol Crystallogr. 2003 Jan;59(Pt 1):67-72. Epub 2002, Dec 19. PMID:12499541

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