1m7w

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[[Image:1m7w.gif|left|200px]]
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{{Seed}}
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[[Image:1m7w.png|left|200px]]
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{{STRUCTURE_1m7w| PDB=1m7w | SCENE= }}
{{STRUCTURE_1m7w| PDB=1m7w | SCENE= }}
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'''HNF4a ligand binding domain with bound fatty acid'''
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===HNF4a ligand binding domain with bound fatty acid===
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==Overview==
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HNF4 alpha is an orphan member of the nuclear receptor family with prominent functions in liver, gut, kidney and pancreatic beta cells. We have solved the x-ray crystal structure of the HNF4 alpha ligand binding domain, which adopts a canonical fold. Two conformational states are present within each homodimer: an open form with alpha helix 12 (alpha 12) extended and collinear with alpha 10 and a closed form with alpha 12 folded against the body of the domain. Although the protein was crystallized without added ligands, the ligand binding pockets of both closed and open forms contain fatty acids. The carboxylic acid headgroup of the fatty acid ion pairs with the guanidinium group of Arg(226) at one end of the ligand binding pocket, while the aliphatic chain fills a long, narrow channel that is lined with hydrophobic residues. These findings suggest that fatty acids are endogenous ligands for HNF4 alpha and establish a framework for understanding how HNF4 alpha activity is enhanced by ligand binding and diminished by MODY1 mutations.
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(as it appears on PubMed at http://www.pubmed.gov), where 12193589 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12193589}}
==About this Structure==
==About this Structure==
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[[Category: Shoelson, S E.]]
[[Category: Shoelson, S E.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:44:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:24:31 2008''

Revision as of 20:24, 2 July 2008

Image:1m7w.png

Template:STRUCTURE 1m7w

HNF4a ligand binding domain with bound fatty acid

Template:ABSTRACT PUBMED 12193589

About this Structure

1M7W is a Single protein structure of sequence from Rattus rattus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand., Dhe-Paganon S, Duda K, Iwamoto M, Chi YI, Shoelson SE, J Biol Chem. 2002 Oct 11;277(41):37973-6. Epub 2002 Aug 21. PMID:12193589

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