1m8o

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[[Image:1m8o.jpg|left|200px]]
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{{Seed}}
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[[Image:1m8o.png|left|200px]]
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{{STRUCTURE_1m8o| PDB=1m8o | SCENE= }}
{{STRUCTURE_1m8o| PDB=1m8o | SCENE= }}
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'''Platelet integrin alfaIIb-beta3 cytoplasmic domain'''
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===Platelet integrin alfaIIb-beta3 cytoplasmic domain===
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==Overview==
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Activation of the ligand binding function of integrin heterodimers requires transmission of an "inside-out" signal from their small intracellular segments to their large extracellular domains. The structure of the cytoplasmic domain of a prototypic integrin alpha(IIb)beta(3) has been solved by NMR and reveals multiple hydrophobic and electrostatic contacts within the membrane-proximal helices of its alpha and the beta cytoplasmic tails. The interface interactions are disrupted by point mutations or the cytoskeletal protein talin that are known to activate the receptor. These results provide a structural mechanism by which a handshake between the alpha and the beta cytoplasmic tails restrains the integrin in a resting state and unclasping of this interaction triggers the inside-out conformational signal that leads to receptor activation.
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The line below this paragraph, {{ABSTRACT_PUBMED_12230976}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12230976 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12230976}}
==About this Structure==
==About this Structure==
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1M8O is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M8O OCA].
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1M8O is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M8O OCA].
==Reference==
==Reference==
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[[Category: Alfa helix]]
[[Category: Alfa helix]]
[[Category: Platelet]]
[[Category: Platelet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:46:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:26:55 2008''

Revision as of 20:26, 2 July 2008

Image:1m8o.png

Template:STRUCTURE 1m8o

Platelet integrin alfaIIb-beta3 cytoplasmic domain

Template:ABSTRACT PUBMED 12230976

About this Structure

1M8O is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face., Vinogradova O, Velyvis A, Velyviene A, Hu B, Haas T, Plow E, Qin J, Cell. 2002 Sep 6;110(5):587-97. PMID:12230976

Page seeded by OCA on Wed Jul 2 23:26:55 2008

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