1m8x

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[[Image:1m8x.gif|left|200px]]
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{{Seed}}
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[[Image:1m8x.png|left|200px]]
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{{STRUCTURE_1m8x| PDB=1m8x | SCENE= }}
{{STRUCTURE_1m8x| PDB=1m8x | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE PUMILIO-HOMOLOGY DOMAIN FROM HUMAN PUMILIO1 IN COMPLEX WITH NRE1-14 RNA'''
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===CRYSTAL STRUCTURE OF THE PUMILIO-HOMOLOGY DOMAIN FROM HUMAN PUMILIO1 IN COMPLEX WITH NRE1-14 RNA===
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==Overview==
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Puf proteins are developmental regulators that control mRNA stability and translation by binding sequences in the 3' untranslated regions of their target mRNAs. We have determined the structure of the RNA binding domain of the human Puf protein, Pumilio1, bound to a high-affinity RNA ligand. The RNA binds the concave surface of the molecule, where each of the protein's eight repeats makes contacts with a different RNA base via three amino acid side chains at conserved positions. We have mutated these three side chains in one repeat, thereby altering the sequence specificity of Pumilio1. Thus, the high affinity and specificity of the PUM-HD for RNA is achieved using multiple copies of a simple repeated motif.
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(as it appears on PubMed at http://www.pubmed.gov), where 12202039 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12202039}}
==About this Structure==
==About this Structure==
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[[Category: Puf domain]]
[[Category: Puf domain]]
[[Category: Pumilio-homology domain]]
[[Category: Pumilio-homology domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:46:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:27:56 2008''

Revision as of 20:28, 2 July 2008

Image:1m8x.png

Template:STRUCTURE 1m8x

CRYSTAL STRUCTURE OF THE PUMILIO-HOMOLOGY DOMAIN FROM HUMAN PUMILIO1 IN COMPLEX WITH NRE1-14 RNA

Template:ABSTRACT PUBMED 12202039

About this Structure

1M8X is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Modular recognition of RNA by a human pumilio-homology domain., Wang X, McLachlan J, Zamore PD, Hall TM, Cell. 2002 Aug 23;110(4):501-12. PMID:12202039

Page seeded by OCA on Wed Jul 2 23:27:56 2008

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