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1m9z

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[[Image:1m9z.gif|left|200px]]
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{{Seed}}
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[[Image:1m9z.png|left|200px]]
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{{STRUCTURE_1m9z| PDB=1m9z | SCENE= }}
{{STRUCTURE_1m9z| PDB=1m9z | SCENE= }}
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'''CRYSTAL STRUCTURE OF HUMAN TGF-BETA TYPE II RECEPTOR LIGAND BINDING DOMAIN'''
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===CRYSTAL STRUCTURE OF HUMAN TGF-BETA TYPE II RECEPTOR LIGAND BINDING DOMAIN===
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==Overview==
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Transforming growth factor beta (TGF-beta) is involved in a wide range of biological functions including development, carcinogenesis, and immune regulation. Here we report the 1.1 A resolution crystal structure of human TGF-beta type II receptor ectodomain (TBRII). The overall structure of TBRII is similar to that of activin type II receptor ectodomain (ActRII) and bone morphogenic protein receptor type IA (BRIA). It displays a three-finger toxin fold with fingers formed by the beta strand pairs beta1-beta2, beta3-beta4, and beta5-beta6. The first finger in the TBRII is significantly longer than in ActRII and BRIA and folds tightly between the second finger and the C terminus. Surface charge distributions and hydrophobic patches predict potential TBRII binding sites.
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The line below this paragraph, {{ABSTRACT_PUBMED_12121646}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12121646 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12121646}}
==About this Structure==
==About this Structure==
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[[Category: Sun, P D.]]
[[Category: Sun, P D.]]
[[Category: Three finger toxin fold]]
[[Category: Three finger toxin fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:48:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:31:42 2008''

Revision as of 20:31, 2 July 2008

Image:1m9z.png

Template:STRUCTURE 1m9z

CRYSTAL STRUCTURE OF HUMAN TGF-BETA TYPE II RECEPTOR LIGAND BINDING DOMAIN

Template:ABSTRACT PUBMED 12121646

About this Structure

1M9Z is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The 1.1 A crystal structure of human TGF-beta type II receptor ligand binding domain., Boesen CC, Radaev S, Motyka SA, Patamawenu A, Sun PD, Structure. 2002 Jul;10(7):913-9. PMID:12121646

Page seeded by OCA on Wed Jul 2 23:31:42 2008

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