1ig7
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(New page: 200px<br /><applet load="1ig7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ig7, resolution 2.20Å" /> '''Msx-1 Homeodomain/DN...)
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Revision as of 15:15, 20 November 2007
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Msx-1 Homeodomain/DNA Complex Structure
Overview
The Msx-1 homeodomain protein plays a crucial role in craniofacial, limb, and nervous system development. Homeodomain DNA-binding domains are, comprised of 60 amino acids that show a high degree of evolutionary, conservation. We have determined the structure of the Msx-1 homeodomain, complexed to DNA at 2.2 A resolution. The structure has an unusually, well-ordered N-terminal arm with a unique trajectory across the minor, groove of the DNA. DNA specificity conferred by bases flanking the core, TAAT sequence is explained by well ordered water-mediated interactions at, Q50. Most interactions seen at the TAAT sequence are typical of the, interactions seen in other homeodomain structures. Comparison of the, Msx-1-HD structure to all other high resolution HD-DNA complex structures, indicate a remarkably well-conserved sphere of hydration between the DNA, and protein in these complexes.
About this Structure
1IG7 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the Msx-1 homeodomain/DNA complex., Hovde S, Abate-Shen C, Geiger JH, Biochemistry. 2001 Oct 9;40(40):12013-21. PMID:11580277
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