1mbm

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[[Image:1mbm.jpg|left|200px]]
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{{STRUCTURE_1mbm| PDB=1mbm | SCENE= }}
{{STRUCTURE_1mbm| PDB=1mbm | SCENE= }}
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'''NSP4 proteinase from Equine Arteritis Virus'''
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===NSP4 proteinase from Equine Arteritis Virus===
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==Overview==
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Arteriviruses are enveloped, positive-stranded RNA viruses and include pathogens of major economic concern to the swine- and horse-breeding industries. The arterivirus replicase gene encodes two large precursor polyproteins that are processed by the viral main proteinase nonstructural protein 4 (nsp4). The three-dimensional structure of the 21-kDa nsp4 from the arterivirus prototype equine arteritis virus has been determined to 2.0 A resolution. Nsp4 adopts the smallest known chymotrypsin-like fold with a canonical catalytic triad of Ser-120, His-39, and Asp-65, as well as a novel alpha/beta C-terminal extension domain that may play a role in mediating protein-protein interactions. In different copies of nsp4 in the asymmetric unit, the oxyanion hole adopts either a collapsed inactive conformation or the standard active conformation, which may be a novel way of regulating proteolytic activity.
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(as it appears on PubMed at http://www.pubmed.gov), where 12163505 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12163505}}
==About this Structure==
==About this Structure==
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[[Category: Collapsed oxyanion hole]]
[[Category: Collapsed oxyanion hole]]
[[Category: Serine proteinase]]
[[Category: Serine proteinase]]
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Revision as of 20:37, 2 July 2008

Image:1mbm.png

Template:STRUCTURE 1mbm

NSP4 proteinase from Equine Arteritis Virus

Template:ABSTRACT PUBMED 12163505

About this Structure

1MBM is a Single protein structure of sequence from Equine arteritis virus. Full crystallographic information is available from OCA.

Reference

Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole., Barrette-Ng IH, Ng KK, Mark BL, Van Aken D, Cherney MM, Garen C, Kolodenko Y, Gorbalenya AE, Snijder EJ, James MN, J Biol Chem. 2002 Oct 18;277(42):39960-6. Epub 2002 Aug 5. PMID:12163505

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