1mcv

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{{STRUCTURE_1mcv| PDB=1mcv | SCENE= }}
{{STRUCTURE_1mcv| PDB=1mcv | SCENE= }}
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'''Crystal Structure Analysis of a Hybrid Squash Inhibitor in Complex with Porcine Pancreatic Elastase'''
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===Crystal Structure Analysis of a Hybrid Squash Inhibitor in Complex with Porcine Pancreatic Elastase===
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==Overview==
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The crystal structure of porcine pancreatic elastase in complex with a hybrid squash inhibitor (HEI-TOE I; 28 amino acids) has been determined to a resolution of 1.8 A. To construct the hybrid inhibitor, the trypsin-binding loop of the squash inhibitor from Ecballium elaterium was substituted by the sequence of a peptide that was derived from the third domain of the turkey ovomucoid inhibitor and was optimized to inhibit porcine pancreatic elastase. This modification of the squash inhibitor changed its specificity for trypsin to a specificity for porcine pancreatic elastase. Specific interactions of this hybrid inhibitor with porcine pancreatic elastase and the differences from the interactions of the ovomucoid inhibitor with human leukocyte elastase are discussed. The binding loop of the inhibitor adopts a 'canonical' conformation and the scissile bond Leu-Glu remains intact.
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The line below this paragraph, {{ABSTRACT_PUBMED_12554935}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12554935 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12554935}}
==About this Structure==
==About this Structure==
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[[Category: Elastase-inhibitor complex]]
[[Category: Elastase-inhibitor complex]]
[[Category: Hybrid squash inhibitor]]
[[Category: Hybrid squash inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:53:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:42:04 2008''

Revision as of 20:42, 2 July 2008

Image:1mcv.png

Template:STRUCTURE 1mcv

Crystal Structure Analysis of a Hybrid Squash Inhibitor in Complex with Porcine Pancreatic Elastase

Template:ABSTRACT PUBMED 12554935

About this Structure

1MCV is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Structure of a hybrid squash inhibitor in complex with porcine pancreatic elastase at 1.8 A resolution., Ay J, Hilpert K, Krauss N, Schneider-Mergener J, Hohne W, Acta Crystallogr D Biol Crystallogr. 2003 Feb;59(Pt 2):247-54. Epub 2003, Jan 23. PMID:12554935

Page seeded by OCA on Wed Jul 2 23:42:04 2008

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