1mdw

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[[Image:1mdw.gif|left|200px]]
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{{STRUCTURE_1mdw| PDB=1mdw | SCENE= }}
{{STRUCTURE_1mdw| PDB=1mdw | SCENE= }}
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'''Crystal Structure of Calcium-Bound Protease Core of Calpain II Reveals the Basis for Intrinsic Inactivation'''
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===Crystal Structure of Calcium-Bound Protease Core of Calpain II Reveals the Basis for Intrinsic Inactivation===
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==Overview==
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Uncontrolled activation of calpain can lead to necrotic cell death and irreversible tissue damage. We have discovered an intrinsic mechanism whereby the autolysis-generated protease core fragment of calpain is inactivated through the inherent instability of a key alpha-helix. This auto-inactivation state was captured by the 1.9 A Ca(2+)-bound structure of the protease core from m-calpain, and sequence alignments suggest that it applies to about half of the calpain isoforms. Intact calpain large subunits are also subject to this inhibition, which can be prevented through assembly of the heterodimers. Other isoforms or their released cores are not silenced by this mechanism and might contribute to calpain patho-physiologies.
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(as it appears on PubMed at http://www.pubmed.gov), where 12665854 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12665854}}
==About this Structure==
==About this Structure==
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[[Category: Tryptophan-based active site blockage]]
[[Category: Tryptophan-based active site blockage]]
[[Category: Two cooperative calcium site]]
[[Category: Two cooperative calcium site]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:55:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:45:41 2008''

Revision as of 20:45, 2 July 2008

Image:1mdw.png

Template:STRUCTURE 1mdw

Crystal Structure of Calcium-Bound Protease Core of Calpain II Reveals the Basis for Intrinsic Inactivation

Template:ABSTRACT PUBMED 12665854

About this Structure

1MDW is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Calpain silencing by a reversible intrinsic mechanism., Moldoveanu T, Hosfield CM, Lim D, Jia Z, Davies PL, Nat Struct Biol. 2003 May;10(5):371-8. PMID:12665854

Page seeded by OCA on Wed Jul 2 23:45:41 2008

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