1meg

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{{STRUCTURE_1meg| PDB=1meg | SCENE= }}
{{STRUCTURE_1meg| PDB=1meg | SCENE= }}
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'''CRYSTAL STRUCTURE OF A CARICAIN D158E MUTANT IN COMPLEX WITH E-64'''
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===CRYSTAL STRUCTURE OF A CARICAIN D158E MUTANT IN COMPLEX WITH E-64===
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==Overview==
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The structure of the D158E mutant of caricain (previously known as papaya protease omega) in complex with E-64 has been determined at 2.0 A resolution (overall R factor 19.3%). The structure reveals that the substituted glutamate makes the same pattern of hydrogen bonds as the aspartate in native caricain. This was not anticipated since in the native structure there is insufficient room to accommodate the glutamate side chain. The glutamate is accommodated in the mutant by a local expansion of the structure demonstrating that small structural changes are responsible for the change in activity.
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(as it appears on PubMed at http://www.pubmed.gov), where 8769310 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8769310}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Thiol protease]]
[[Category: Thiol protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:47:29 2008''

Revision as of 20:47, 2 July 2008

Image:1meg.png

Template:STRUCTURE 1meg

CRYSTAL STRUCTURE OF A CARICAIN D158E MUTANT IN COMPLEX WITH E-64

Template:ABSTRACT PUBMED 8769310

About this Structure

1MEG is a Single protein structure of sequence from Carica papaya. Full crystallographic information is available from OCA.

Reference

Crystal structure of a caricain D158E mutant in complex with E-64., Katerelos NA, Taylor MA, Scott M, Goodenough PW, Pickersgill RW, FEBS Lett. 1996 Aug 19;392(1):35-9. PMID:8769310

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