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1mek

From Proteopedia

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[[Image:1mek.gif|left|200px]]
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{{STRUCTURE_1mek| PDB=1mek | SCENE= }}
{{STRUCTURE_1mek| PDB=1mek | SCENE= }}
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'''HUMAN PROTEIN DISULFIDE ISOMERASE, NMR, 40 STRUCTURES'''
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===HUMAN PROTEIN DISULFIDE ISOMERASE, NMR, 40 STRUCTURES===
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==Overview==
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As a first step in dissecting the structure of human protein disulfide isomerase (PDI), the structure of a fragment corresponding to the first 120 residues of its sequence has been determined using heteronuclear multidimensional NMR techniques. As expected from its primary structure homology, the fragment has the thioredoxin fold. Similarities and differences in their structures help to explain why thioredoxins are reductants, whereas PDI is an oxidant of protein thiol groups. The results confirm that PDI has a modular, multidomain structure, which will facilitate its structural and functional characterization.
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(as it appears on PubMed at http://www.pubmed.gov), where 8672469 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8672469}}
==About this Structure==
==About this Structure==
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1MEK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MEK OCA].
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1MEK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MEK OCA].
==Reference==
==Reference==
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[[Category: Isomerase]]
[[Category: Isomerase]]
[[Category: Redox-active center]]
[[Category: Redox-active center]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:56:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:47:58 2008''

Revision as of 20:48, 2 July 2008

Image:1mek.png

Template:STRUCTURE 1mek

HUMAN PROTEIN DISULFIDE ISOMERASE, NMR, 40 STRUCTURES

Template:ABSTRACT PUBMED 8672469

About this Structure

1MEK is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure determination of the N-terminal thioredoxin-like domain of protein disulfide isomerase using multidimensional heteronuclear 13C/15N NMR spectroscopy., Kemmink J, Darby NJ, Dijkstra K, Nilges M, Creighton TE, Biochemistry. 1996 Jun 18;35(24):7684-91. PMID:8672469

Page seeded by OCA on Wed Jul 2 23:47:58 2008

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