1mey

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[[Image:1mey.gif|left|200px]]
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{{STRUCTURE_1mey| PDB=1mey | SCENE= }}
{{STRUCTURE_1mey| PDB=1mey | SCENE= }}
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'''CRYSTAL STRUCTURE OF A DESIGNED ZINC FINGER PROTEIN BOUND TO DNA'''
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===CRYSTAL STRUCTURE OF A DESIGNED ZINC FINGER PROTEIN BOUND TO DNA===
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==Overview==
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Considerable recent effort has been devoted to the design and selection of sequence-specific DNA binding proteins based on tandem arrays of Cys2His2 zinc finger domains. While the DNA binding properties of these designed proteins have been studied extensively, the structural basis for site-specific binding has not been examined experimentally. Here we report the crystal structure of a complex between a protein comprised of three consensus-sequence-based zinc finger domains and an oligonucleotide corresponding to a favourable DNA binding site. This structure reveals relatively simple modular interactions and structural adaptations that compensate for differences in contact residue side-chain lengths.
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The line below this paragraph, {{ABSTRACT_PUBMED_8901872}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8901872 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8901872}}
==About this Structure==
==About this Structure==
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[[Category: Protein-dna interaction]]
[[Category: Protein-dna interaction]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:57:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:49:24 2008''

Revision as of 20:49, 2 July 2008

Image:1mey.png

Template:STRUCTURE 1mey

CRYSTAL STRUCTURE OF A DESIGNED ZINC FINGER PROTEIN BOUND TO DNA

Template:ABSTRACT PUBMED 8901872

About this Structure

Full crystallographic information is available from OCA.

Reference

A 2.2 A resolution crystal structure of a designed zinc finger protein bound to DNA., Kim CA, Berg JM, Nat Struct Biol. 1996 Nov;3(11):940-5. PMID:8901872

Page seeded by OCA on Wed Jul 2 23:49:24 2008

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