1mf8

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[[Image:1mf8.gif|left|200px]]
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{{STRUCTURE_1mf8| PDB=1mf8 | SCENE= }}
{{STRUCTURE_1mf8| PDB=1mf8 | SCENE= }}
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'''Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin'''
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===Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin===
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==Overview==
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Calcineurin (Cn), a Ca(2+)/calmodulin-dependent Ser/Thr protein phosphatase, is an important participant in signaling pathways that activate T cells. It is the target of the immunosuppressive drugs cyclosporin A (CsA) and FK506. These drugs bind proteins known as cyclophilin (Cyp) and FK506-binding protein, respectively, and the drug-protein complexes in turn inhibit Cn. We report the crystal structure of a Cyp/CsA/Cn ternary complex, determined to a resolution of 3.1 A. Residues 3-9 of CsA, particularly N-methyl leucines 4 and 6, and Trp-121 of Cyp form a composite surface for interaction with Cn. The hydrophobic interface buries two hydrogen bonds. The structure accounts clearly for the effects of mutations in Cn on CsA-resistance and for the way modifications of CsA alter immunosuppressive activity.
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(as it appears on PubMed at http://www.pubmed.gov), where 12357034 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12357034}}
==About this Structure==
==About this Structure==
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[[Category: Immunosuppressant]]
[[Category: Immunosuppressant]]
[[Category: Protein-drug complex]]
[[Category: Protein-drug complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:57:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:50:22 2008''

Revision as of 20:50, 2 July 2008

Image:1mf8.png

Template:STRUCTURE 1mf8

Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin

Template:ABSTRACT PUBMED 12357034

About this Structure

1MF8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin., Jin L, Harrison SC, Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13522-6. Epub 2002 Sep 30. PMID:12357034

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