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1mfe

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[[Image:1mfe.gif|left|200px]]
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{{STRUCTURE_1mfe| PDB=1mfe | SCENE= }}
{{STRUCTURE_1mfe| PDB=1mfe | SCENE= }}
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'''RECOGNITION OF A CELL-SURFACE OLIGO-SACCHARIDE OF PATHOGENIC SALMONELLA BY AN ANTIBODY FAB FRAGMENT'''
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===RECOGNITION OF A CELL-SURFACE OLIGO-SACCHARIDE OF PATHOGENIC SALMONELLA BY AN ANTIBODY FAB FRAGMENT===
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==Overview==
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The 2.05 angstrom (A) resolution crystal structure of a dodecasaccharide-Fab complex revealed an unusual carbohydrate recognition site, defined by aromatic amino acids and a structured water molecule, rather than the carboxylic acid and amide side chains and a structured water molecule, rather than the carboxylic acid and amide side chains that are features of transport and other carbohydrate binding proteins. A trisaccharide epitope of a branched bacterial lipopolysaccharide fills this hydrophobic pocket (8 A deep by 7 A wide) in an entropy-assisted association (association constant = 2.05 x 10(5) liters per mole, enthalpy = -20.5 +/- 1.7 kilojoules per mole, and temperature times entropy = +10.0 +/- 2.9 kilojoules per mole). The requirement for the complementarity of van der Waals surfaces and the requirements of saccharide-saccharide and protein-saccharide hydrogen-bonding networks determine the antigen conformation adopted in the bound state.
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The line below this paragraph, {{ABSTRACT_PUBMED_1713710}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1713710 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1713710}}
==About this Structure==
==About this Structure==
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[[Category: Cygler, M.]]
[[Category: Cygler, M.]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:58:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:51:01 2008''

Revision as of 20:51, 2 July 2008

Image:1mfe.png

Template:STRUCTURE 1mfe

RECOGNITION OF A CELL-SURFACE OLIGO-SACCHARIDE OF PATHOGENIC SALMONELLA BY AN ANTIBODY FAB FRAGMENT

Template:ABSTRACT PUBMED 1713710

About this Structure

1MFE is a Protein complex structure. Full crystallographic information is available from OCA.

Reference

Recognition of a cell-surface oligosaccharide of pathogenic Salmonella by an antibody Fab fragment., Cygler M, Rose DR, Bundle DR, Science. 1991 Jul 26;253(5018):442-5. PMID:1713710

Page seeded by OCA on Wed Jul 2 23:51:01 2008

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