1mfe

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1mfe.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1mfe.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1mfe| PDB=1mfe | SCENE= }}
{{STRUCTURE_1mfe| PDB=1mfe | SCENE= }}
-
'''RECOGNITION OF A CELL-SURFACE OLIGO-SACCHARIDE OF PATHOGENIC SALMONELLA BY AN ANTIBODY FAB FRAGMENT'''
+
===RECOGNITION OF A CELL-SURFACE OLIGO-SACCHARIDE OF PATHOGENIC SALMONELLA BY AN ANTIBODY FAB FRAGMENT===
-
==Overview==
+
<!--
-
The 2.05 angstrom (A) resolution crystal structure of a dodecasaccharide-Fab complex revealed an unusual carbohydrate recognition site, defined by aromatic amino acids and a structured water molecule, rather than the carboxylic acid and amide side chains and a structured water molecule, rather than the carboxylic acid and amide side chains that are features of transport and other carbohydrate binding proteins. A trisaccharide epitope of a branched bacterial lipopolysaccharide fills this hydrophobic pocket (8 A deep by 7 A wide) in an entropy-assisted association (association constant = 2.05 x 10(5) liters per mole, enthalpy = -20.5 +/- 1.7 kilojoules per mole, and temperature times entropy = +10.0 +/- 2.9 kilojoules per mole). The requirement for the complementarity of van der Waals surfaces and the requirements of saccharide-saccharide and protein-saccharide hydrogen-bonding networks determine the antigen conformation adopted in the bound state.
+
The line below this paragraph, {{ABSTRACT_PUBMED_1713710}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 1713710 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_1713710}}
==About this Structure==
==About this Structure==
Line 23: Line 27:
[[Category: Cygler, M.]]
[[Category: Cygler, M.]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:58:02 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:51:01 2008''

Revision as of 20:51, 2 July 2008

Image:1mfe.png

Template:STRUCTURE 1mfe

RECOGNITION OF A CELL-SURFACE OLIGO-SACCHARIDE OF PATHOGENIC SALMONELLA BY AN ANTIBODY FAB FRAGMENT

Template:ABSTRACT PUBMED 1713710

About this Structure

1MFE is a Protein complex structure. Full crystallographic information is available from OCA.

Reference

Recognition of a cell-surface oligosaccharide of pathogenic Salmonella by an antibody Fab fragment., Cygler M, Rose DR, Bundle DR, Science. 1991 Jul 26;253(5018):442-5. PMID:1713710

Page seeded by OCA on Wed Jul 2 23:51:01 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mfe"
Personal tools