1mh1

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{{STRUCTURE_1mh1| PDB=1mh1 | SCENE= }}
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'''SMALL G-PROTEIN'''
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===SMALL G-PROTEIN===
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==Overview==
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The crystal structure of human rac1, a member of the rho family of small G-proteins, complexed with the non-hydrolysable GTP analogue, guanosine-5'-(beta gamma-imino)triphosphate (GMPPNP), has been determined by X-ray analysis at a resolution of 1.38 A. Comparison with the structure of H-ras indicates that rac1 has an extra alpha-helical domain that is characteristic of the rho G proteins, and may be involved in the signalling pathway of this family.
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{{ABSTRACT_PUBMED_9033596}}
==Disease==
==Disease==
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[[Category: Rho family]]
[[Category: Rho family]]
[[Category: Small g-protein]]
[[Category: Small g-protein]]
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Revision as of 20:56, 2 July 2008

Image:1mh1.png

Template:STRUCTURE 1mh1

Contents

SMALL G-PROTEIN

Template:ABSTRACT PUBMED 9033596

Disease

Known disease associated with this structure: Night blindness, congenital stationery, rhodopsin-related OMIM:[180380], Retinitis pigmentosa, autosomal recessive OMIM:[180380], Retinitis pigmentosa-4, autosomal dominant OMIM:[180380]

About this Structure

1MH1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue., Hirshberg M, Stockley RW, Dodson G, Webb MR, Nat Struct Biol. 1997 Feb;4(2):147-52. PMID:9033596

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