1mhd

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{{STRUCTURE_1mhd| PDB=1mhd | SCENE= }}
{{STRUCTURE_1mhd| PDB=1mhd | SCENE= }}
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'''CRYSTAL STRUCTURE OF A SMAD MH1 DOMAIN BOUND TO DNA'''
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===CRYSTAL STRUCTURE OF A SMAD MH1 DOMAIN BOUND TO DNA===
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==Overview==
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The Smad family of proteins, which are frequently targeted by tumorigenic mutations in cancer, mediate TGF-beta signaling from cell membrane to nucleus. The crystal structure of a Smad3 MH1 domain bound to an optimal DNA sequence determined at 2.8 A resolution reveals a novel DNA-binding motif. In the crystals, base-specific DNA recognition is provided exclusively by a conserved 11-residue beta hairpin that is embedded in the major groove of DNA. A surface loop region, to which tumorigenic mutations map, has been identified as a functional surface important for Smad activity. This structure establishes a framework for understanding how Smad proteins may act in concert with other transcription factors in the regulation of TGF-beta-responsive genes.
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==About this Structure==
==About this Structure==
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[[Category: Smad binding element]]
[[Category: Smad binding element]]
[[Category: Smad3 mh1]]
[[Category: Smad3 mh1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:01:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:57:53 2008''

Revision as of 20:57, 2 July 2008

Image:1mhd.png

Template:STRUCTURE 1mhd

CRYSTAL STRUCTURE OF A SMAD MH1 DOMAIN BOUND TO DNA

Template:ABSTRACT PUBMED 9741623

About this Structure

1MHD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling., Shi Y, Wang YF, Jayaraman L, Yang H, Massague J, Pavletich NP, Cell. 1998 Sep 4;94(5):585-94. PMID:9741623

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