This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1mhd

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1mhd.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1mhd.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1mhd| PDB=1mhd | SCENE= }}
{{STRUCTURE_1mhd| PDB=1mhd | SCENE= }}
-
'''CRYSTAL STRUCTURE OF A SMAD MH1 DOMAIN BOUND TO DNA'''
+
===CRYSTAL STRUCTURE OF A SMAD MH1 DOMAIN BOUND TO DNA===
-
==Overview==
+
<!--
-
The Smad family of proteins, which are frequently targeted by tumorigenic mutations in cancer, mediate TGF-beta signaling from cell membrane to nucleus. The crystal structure of a Smad3 MH1 domain bound to an optimal DNA sequence determined at 2.8 A resolution reveals a novel DNA-binding motif. In the crystals, base-specific DNA recognition is provided exclusively by a conserved 11-residue beta hairpin that is embedded in the major groove of DNA. A surface loop region, to which tumorigenic mutations map, has been identified as a functional surface important for Smad activity. This structure establishes a framework for understanding how Smad proteins may act in concert with other transcription factors in the regulation of TGF-beta-responsive genes.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9741623}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9741623 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9741623}}
==About this Structure==
==About this Structure==
Line 26: Line 30:
[[Category: Smad binding element]]
[[Category: Smad binding element]]
[[Category: Smad3 mh1]]
[[Category: Smad3 mh1]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:01:50 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:57:53 2008''

Revision as of 20:57, 2 July 2008

Image:1mhd.png

Template:STRUCTURE 1mhd

CRYSTAL STRUCTURE OF A SMAD MH1 DOMAIN BOUND TO DNA

Template:ABSTRACT PUBMED 9741623

About this Structure

1MHD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling., Shi Y, Wang YF, Jayaraman L, Yang H, Massague J, Pavletich NP, Cell. 1998 Sep 4;94(5):585-94. PMID:9741623

Page seeded by OCA on Wed Jul 2 23:57:53 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mhd"
Personal tools