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1mhh

From Proteopedia

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[[Image:1mhh.gif|left|200px]]
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{{STRUCTURE_1mhh| PDB=1mhh | SCENE= }}
{{STRUCTURE_1mhh| PDB=1mhh | SCENE= }}
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'''Antibody-antigen complex'''
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===Antibody-antigen complex===
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==Overview==
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The multidomain bacterial surface protein L (PpL) is a virulence factor expressed by only 10% of Peptostreptococcus magnus strains, and its expression is correlated with bacterial vaginosis. The molecular basis for its ability to recognize 60% of mammalian immunoglobulin light chain variable regions (V(L)) has been described recently by x-ray crystallography, which suggested the presence of two V(L) binding sites on each protein L domain (Graille, M., Stura, E. A., Housden, N. G., Beckingham, J. A., Bottomley, S. P., Beale, D., Taussig, M. J., Sutton, B. J., Gore, M. G., and Charbonnier, J. (2001) Structure 9, 679-687). Here, we report the crystal structure at 2.1 A resolution of a protein L mutant complexed to an Fab' fragment with only 50% of the V(L) residues interacting with PpL site 1 conserved. Comparison of the site 1 interface from both structures shows how protein L is able to accommodate these sequence differences and therefore bind to a large repertoire of Ig. The x-ray structure and NMR results confirm the existence of two V(L) binding sites on a single protein L domain. These sites exhibit a remarkable structural mimicry of growth factors binding to their receptors. This could explain the protein L superantigenic activity on human B lymphocytes.
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(as it appears on PubMed at http://www.pubmed.gov), where 12221088 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12221088}}
==About this Structure==
==About this Structure==
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[[Category: B cell superantigen]]
[[Category: B cell superantigen]]
[[Category: Immunoglobulin binding protein]]
[[Category: Immunoglobulin binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:02:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:58:04 2008''

Revision as of 20:58, 2 July 2008

Image:1mhh.png

Template:STRUCTURE 1mhh

Antibody-antigen complex

Template:ABSTRACT PUBMED 12221088

About this Structure

Full crystallographic information is available from OCA.

Reference

Evidence for plasticity and structural mimicry at the immunoglobulin light chain-protein L interface., Graille M, Harrison S, Crump MP, Findlow SC, Housden NG, Muller BH, Battail-Poirot N, Sibai G, Sutton BJ, Taussig MJ, Jolivet-Reynaud C, Gore MG, Stura EA, J Biol Chem. 2002 Dec 6;277(49):47500-6. Epub 2002 Sep 8. PMID:12221088

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